Biological function of furin in viral infections
Zhongguo Bingdubing Zazhi = Chinese Journal of Viral Diseases
; - (3):209, 2021.
Article
in English
| ProQuest Central | ID: covidwho-1329332
ABSTRACT
Most viruses require their glycoproteins to be hydrolyzed in order to enter host cells.In some cases, the severability of viral glycoproteins is a determinant of their virulence.These viral glycoproteins can be cleaved by one or more proteases in host cells with furin as the common one.Furin further promotes viral infection by identifying specific amino acid sequences in glycoprotein precursors.Morever, furin plays a critical role in the infections of many viruses including human immunodeficiency virus, flavivirus, filamentavirus and coronavirus, and is considered as a promising drug treatment and prevention target.In this review, we summarize the biological background of furin and its hydrolysis function to viral glycoproteins.
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Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Zhongguo Bingdubing Zazhi = Chinese Journal of Viral Diseases
Year:
2021
Document Type:
Article
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