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Computational model of trachea-alveoli gas movement during spontaneous breathing.
Jiménez-Posada, L D; Maya, Juan C; Sánchez-Ocampo, M; López-Isaza, S; Cortes-Ospina, S; Montagut-Ferizzola, Y J; Torres, R.
  • Jiménez-Posada LD; Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: leon.jimenez@eia.edu.co.
  • Maya JC; Universidad Nacional de Colombia - Sede Medellín, Facultad de Minas - Departamento de Procesos y Energía - TAYEA, Cr 80 No 65 - 233, Medellín, 050034, Colombia. Electronic address: jcmaya@unal.edu.co.
  • Sánchez-Ocampo M; Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: maria.sanchez22@eia.edu.co.
  • López-Isaza S; Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: sergio.lopez@eia.edu.co.
  • Cortes-Ospina S; Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: Santiago.cortes80@eia.edu.co.
  • Montagut-Ferizzola YJ; Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: yeison.montagut@eia.edu.co.
  • Torres R; Universidad EIA, Envigado, Antioquia, Colombia. Electronic address: robinson.torres@eia.edu.co.
Respir Physiol Neurobiol ; 294: 103767, 2021 12.
Article in English | MEDLINE | ID: covidwho-1330032
ABSTRACT
A computational model of the transport of gases involved in spontaneous breathing, from the trachea inlet to the alveoli was developed for healthy patients. Convective and diffusive transport mechanisms were considered simultaneously, using a diffusion coefficient (D) that has considered the four main species of gases present in the exchange carried out by the human lung, nitrogen (N2), oxygen (O2), carbon dioxide (CO2) and water vapor (H2O). A Matlab® script was programmed to simulate the trachea-alveolus gas exchange model under three respiratory frequencies 12, 24 and 40 breaths per minute (BPM), each with three diaphragmatic movements of 2 cm, 4 cm, and 6 cm. During the simulations, the CO2 inlet concentrations in the alveoli and the O2 concentration at the inlet of the trachea were kept constant. A simplified but stable model of mass transport between the trachea and alveoli was obtained, allowing the concentrations to be determined dynamically at the selected test points in the airway.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Alveoli / Respiration / Trachea / Pulmonary Gas Exchange / Models, Theoretical Limits: Humans Language: English Journal: Respir Physiol Neurobiol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Alveoli / Respiration / Trachea / Pulmonary Gas Exchange / Models, Theoretical Limits: Humans Language: English Journal: Respir Physiol Neurobiol Year: 2021 Document Type: Article