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Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management.
Chavda, Vivek P; Vora, Lalitkumar K; Pandya, Anjali K; Patravale, Vandana B.
  • Chavda VP; Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad 380009, India. Electronic address: L.Vora@qub.ac.uk.
  • Vora LK; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, BT9 7BL, UK. Electronic address: L.Vora@qub.ac.uk.
  • Pandya AK; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400 019, India.
  • Patravale VB; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400 019, India.
Drug Discov Today ; 26(11): 2619-2636, 2021 11.
Article in English | MEDLINE | ID: covidwho-1330754
ABSTRACT
Unlike conventional Coronavirus 2019 (COVID-19) vaccines, intranasal vaccines display a superior advantage because the nasal mucosa is often the initial site of infection. Preclinical and clinical studies concerning intranasal immunization elicit high neutralizing antibody generation and mucosal IgA and T cell responses that avoid severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in both; the upper and lower respiratory tract. A nasal formulation is non-invasive with high appeal to patients. Intranasal vaccines enable self-administration and can be designed to survive at ambient temperatures, thereby simplifying logistical aspects of transport and storage. In this review, we provide an overview of nasal vaccines with a focus on formulation development as well as ongoing preclinical and clinical studies for SARS-CoV-2 intranasal vaccine products.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Administration, Intranasal / Drug Development / COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Drug Discov Today Journal subject: Pharmacology / Drug Therapy Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Administration, Intranasal / Drug Development / COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Drug Discov Today Journal subject: Pharmacology / Drug Therapy Year: 2021 Document Type: Article