Autoimmune hepatitis triggered by SARS-CoV-2 vaccination.
J Autoimmun
; 123: 102710, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1330939
ABSTRACT
The development of autoimmune diseases has been reported after SARS-CoV-2 infection. Vaccination against SARS-CoV-2 could also trigger auto-immunity, as it has been described with other vaccines. An aberrant immune response induced by molecular mimicry and bystander activation, especially in predisposed individuals, is a potential mechanism. We report the case of a 76-year-old woman with Hashimoto thyroiditis and prior COVID-19 infection who developed severe autoimmune hepatitis (with typical features including strongly positive anti-smooth muscle antibody and markedly elevated immunoglobulins G, as well as typical histological findings) following SARS-CoV-2 vaccination (mRNA-1273 SARS-CoV-2 vaccine, Moderna®). The link between SARS-CoV-2 vaccination and the development of autoimmune diseases needs to be further investigated. Although a causality relationship cannot be proven, caution may be warranted when vaccinating individuals with known autoimmune diseases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Autoantibodies
/
Vaccination
/
Hepatitis, Autoimmune
/
COVID-19 Vaccines
/
SARS-CoV-2
/
COVID-19
Type of study:
Case report
/
Observational study
Topics:
Long Covid
/
Vaccines
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
J Autoimmun
Journal subject:
Allergy and Immunology
Year:
2021
Document Type:
Article
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