Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study.
J Steroid Biochem Mol Biol
; 213: 105958, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1331009
ABSTRACT
BACKGROUND:
The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.METHODS:
Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000 IU per month, or 80,000 IU or 100,000 IU or 200,000 IU every 2-3 months), or daily supplementation with 800 IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration.RESULTS:
76.1 % (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6 % (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23 [95 %CI 0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008).CONCLUSIONS:
Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Cholecalciferol
/
Dietary Supplements
/
Malnutrition
/
COVID-19
/
Cardiomyopathies
/
Neoplasms
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Traditional medicine
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J Steroid Biochem Mol Biol
Journal subject:
Molecular Biology
/
Biochemistry
Year:
2021
Document Type:
Article
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