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Updates on What ACS Reported: Emerging Evidences of COVID-19 with Nervous System Involvement.
Baig, Abdul Mannan.
  • Baig AM; Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.
ACS Chem Neurosci ; 11(9): 1204-1205, 2020 05 06.
Article in English | MEDLINE | ID: covidwho-133102
ABSTRACT
With the ongoing pandemic of coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), our knowledge of the pathogenesis of COVID-19 is still in its infancy. Almost every aspect of the pathogen remains largely unknown, ranging from mechanisms involved in infection transmission, interplay with the human immune system, and covert mechanisms of end-organ damage. COVID-19 has manifested itself worldwide with a syndromic appearance that is dominated by respiratory dysregulations. While clinicians are focused on correcting respiratory homeostasis, echoing the original SARS, SARS-CoV-2 is also invading other end-organs, which may not exhibit overt clinical features. Nervous system involvement was not initially considered to play a significant role in patients with COVID-19. However, since this viewpoint was initially published, multiple studies have been released regarding the possible neurovirulence of SARS-CoV-2. In our previous viewpoint, we implored our colleagues to recognize the covert tactics of SARS-CoV-2 and emphasized that symptoms like anosmia, dysgeusia, ataxia, and altered mental status could be early signs of the neurotropic potential of this virus. The past few weeks, after the viewpoint surfaced, it was noticed that it has enabled clinicians and healthcare professionals to compute the neurovirulence associated with SARS-CoV-2 in COVID-19 patients, as evidenced by very recently reported studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Nervous System Type of study: Prognostic study Limits: Humans Language: English Journal: ACS Chem Neurosci Year: 2020 Document Type: Article Affiliation country: Acschemneuro.0c00181

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Nervous System Type of study: Prognostic study Limits: Humans Language: English Journal: ACS Chem Neurosci Year: 2020 Document Type: Article Affiliation country: Acschemneuro.0c00181