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Post-intensive care syndrome after a critical COVID-19: cohort study from a Belgian follow-up clinic.
Rousseau, Anne-Françoise; Minguet, Pauline; Colson, Camille; Kellens, Isabelle; Chaabane, Sourour; Delanaye, Pierre; Cavalier, Etienne; Chase, J Geoffrey; Lambermont, Bernard; Misset, Benoit.
  • Rousseau AF; Department of Intensive Care and Burn Center, University Hospital of Liège, Sart-Tilman B35, 4000, Liège, Belgium. afrousseau@chuliege.be.
  • Minguet P; Department of Intensive Care and Burn Center, University Hospital of Liège, Sart-Tilman B35, 4000, Liège, Belgium.
  • Colson C; Department of Intensive Care and Burn Center, University Hospital of Liège, Sart-Tilman B35, 4000, Liège, Belgium.
  • Kellens I; Department of Intensive Care and Burn Center, University Hospital of Liège, Sart-Tilman B35, 4000, Liège, Belgium.
  • Chaabane S; Department of Intensive Care and Burn Center, University Hospital of Liège, Sart-Tilman B35, 4000, Liège, Belgium.
  • Delanaye P; Department of Nephrology, University Hospital of Liège, Liège, Belgium.
  • Cavalier E; Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nimes, France.
  • Chase JG; Department of Clinical Chemistry, University Hospital of Liège, Liège, Belgium.
  • Lambermont B; Department of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand.
  • Misset B; Department of Intensive Care and Burn Center, University Hospital of Liège, Sart-Tilman B35, 4000, Liège, Belgium.
Ann Intensive Care ; 11(1): 118, 2021 Jul 29.
Article in English | MEDLINE | ID: covidwho-1331957
ABSTRACT

PURPOSE:

Many patients with coronavirus disease 2019 (COVID-19) required critical care. Mid-term outcomes of the survivors need to be assessed. The objective of this single-center cohort study was to describe their physical, cognitive, psychological, and biological outcomes at 3 months following intensive care unit (ICU)-discharge (M3). PATIENTS AND

METHODS:

All COVID-19 adults who survived an ICU stay ≥ 7 days and attended the M3 consultation at our multidisciplinary follow-up clinic were involved. They benefited from a standardized assessment, addressing health-related quality of life (EQ-5D-3L), sleep disorders (PSQI), and the three principal components of post-intensive care syndrome (PICS) physical status (Barthel index, handgrip and quadriceps strength), mental health disorders (HADS and IES-R), and cognitive impairment (MoCA). Biological parameters referred to C-reactive protein and creatinine.

RESULTS:

Among the 92 patients admitted to our ICU for COVID-19, 42 survived a prolonged ICU stay and 32 (80%) attended the M3 follow-up visit. Their median age was 62 [49-68] years, 72% were male, and nearly half received inpatient rehabilitation following ICU discharge. At M3, 87.5% (28/32) had not regained their baseline level of daily activities. Only 6.2% (2/32) fully recovered, and had normal scores for the three MoCA, IES-R and Barthel scores. The main observed disorders were PSQI > 5 (75%, 24/32), MoCA < 26 (44%, 14/32), Barthel < 100 (31%, 10/32) and IES-R ≥ 33 (28%, 9/32). Combined disorders were observed in 13/32 (40.6%) of the patients. The EQ-5D-3L visual scale was rated at 71 [61-80]. A quarter of patients (8/32) demonstrated a persistent inflammation based on CRP blood level (9.3 [6.8-17.7] mg/L).

CONCLUSION:

The burden of severe COVID-19 and prolonged ICU stay was considerable in the present cohort after 3 months, affecting both functional status and biological parameters. These data are an argument on the need for closed follow-up for critically ill COVID-19 survivors.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Ann Intensive Care Year: 2021 Document Type: Article Affiliation country: S13613-021-00910-9

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Ann Intensive Care Year: 2021 Document Type: Article Affiliation country: S13613-021-00910-9