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Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies.
Wadhwa, Ashutosh; Yin, Sherry; Freeman, Brandi; Hershow, Rebecca B; Killerby, Marie; Yousaf, Anna R; Lester, Sandra; Mills, Lisa; Buono, Sean A; Pomeroy, Mary; Owusu, Daniel; Chu, Victoria T; Tate, Jacqueline E; Bhattacharyya, Sanjib; Hall, Patricia; Thornburg, Natalie J; Kirking, Hannah L.
  • Wadhwa A; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Yin S; Laboratory Leadership Service, CDC, Atlanta, Georgia, United States of America.
  • Freeman B; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Hershow RB; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Killerby M; Laboratory Leadership Service, CDC, Atlanta, Georgia, United States of America.
  • Yousaf AR; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Lester S; Epidemic Intelligence Service, CDC, Atlanta, Georgia, United States of America.
  • Mills L; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Buono SA; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Pomeroy M; Epidemic Intelligence Service, CDC, Atlanta, Georgia, United States of America.
  • Owusu D; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Chu VT; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Tate JE; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Bhattacharyya S; Laboratory Leadership Service, CDC, Atlanta, Georgia, United States of America.
  • Hall P; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
  • Thornburg NJ; Epidemic Intelligence Service, CDC, Atlanta, Georgia, United States of America.
  • Kirking HL; COVID-19 Response Team, CDC, Atlanta, Georgia, United States of America.
PLoS One ; 16(7): e0255208, 2021.
Article in English | MEDLINE | ID: covidwho-1332001
ABSTRACT
Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott ArchitectTM SARS-CoV-2 IgG assay indicated that the assays had high concordance, with rare paired discordant tests results.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Nucleocapsid / Nucleocapsid Proteins / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0255208

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Nucleocapsid / Nucleocapsid Proteins / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0255208