Clinical Predictors of COVID-19 Mortality Among Patients in Intensive Care Units: A Retrospective Study.
Int J Gen Med
; 14: 3719-3728, 2021.
Article
in English
| MEDLINE | ID: covidwho-1332058
ABSTRACT
OBJECTIVE:
The ongoing pandemic of the coronavirus disease 2019 (COVID-19), which originated from Wuhan, China, has been identified to be caused by the novel beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been spreading rapidly worldwide within just a few months. Our aims were to analyze clinical and laboratory abnormalities in ICU patients with COVID-19, in order to define which predictors can distinguish between those who are at higher risk of developing fatal versus non-fatal forms of the disease.METHODS:
A descriptive cross-sectional survey was used; demographics, comorbidities, symptoms, laboratory parameters at ICU admission, and clinical outcomes for the adult patients admitted to ICU were collected from five hospitals in Saudi Arabia.RESULTS:
A total of 86 patients with COVID-19 admitted in ICU, 50 patients died, 23 recovered, and 13 were still admitted, with a mortality rate of 58.1%. Septic shock (OR (95% CI) 58.1 (5.97-7812.8), p < 0.001) and acute kidney injury (AKI) (OR (95% CI) 7.279 (1.191-65.43), p = 0.032) had a significant impact on mortality. Cox proportional-hazards regression analysis revealed that septic shock (HR (95% CI) 9.502 (2.958-30.524), p < 0.001) and neutrophil count (HR (95% CI) 1.053 (1.023-1.085), p < 0.001) were significant predictors for mortality.CONCLUSION:
Septic shock, AKI, and high neutrophil count were found to be predictive of death in these patients. Further studies are needed to aid efficient recognition and management of severe COVID-19 patients in our population. .
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
Int J Gen Med
Year:
2021
Document Type:
Article
Affiliation country:
IJGM.S313757
Similar
MEDLINE
...
LILACS
LIS