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Immune Signature Linked to COVID-19 Severity: A SARS-Score for Personalized Medicine.
Russick, Jules; Foy, Pierre-Emmanuel; Josseaume, Nathalie; Meylan, Maxime; Hamouda, Nadine Ben; Kirilovsky, Amos; Sissy, Carine El; Tartour, Eric; Smadja, David M; Karras, Alexandre; Hulot, Jean-Sébastien; Livrozet, Marine; Fayol, Antoine; Arlet, Jean-Benoit; Diehl, Jean-Luc; Dragon-Durey, Marie-Agnès; Pagès, Franck; Cremer, Isabelle.
  • Russick J; Centre de Recherche des Cordeliers, Sorbonne Universite, Inserm, Universite de Paris, Team Inflammation, Complement and Cancer, Paris, France.
  • Foy PE; Centre de Recherche des Cordeliers, Sorbonne Universite, Inserm, Universite de Paris, Team Inflammation, Complement and Cancer, Paris, France.
  • Josseaume N; Centre de Recherche des Cordeliers, Sorbonne Universite, Inserm, Universite de Paris, Team Inflammation, Complement and Cancer, Paris, France.
  • Meylan M; Centre de Recherche des Cordeliers, Sorbonne Universite, Inserm, Universite de Paris, Team Inflammation, Complement and Cancer, Paris, France.
  • Hamouda NB; Hopital Europeen Georges Pompidou, AP-HP, Paris, Universite de Paris, Paris, France.
  • Kirilovsky A; Centre de Recherche des Cordeliers, Sorbonne Universite, Inserm, Universite de Paris, Team Integrative Cancer Immunology F-75006, Paris, France.
  • Sissy CE; Sorbonne Universite, Paris, France.
  • Tartour E; Hopital Europeen Georges Pompidou, AP-HP, Paris, Universite de Paris, Paris, France.
  • Smadja DM; Centre de Recherche des Cordeliers, Sorbonne Universite, Inserm, Universite de Paris, Team Integrative Cancer Immunology F-75006, Paris, France.
  • Karras A; Sorbonne Universite, Paris, France.
  • Hulot JS; Hopital Europeen Georges Pompidou, AP-HP, Paris, Universite de Paris, Paris, France.
  • Livrozet M; Centre de Recherche des Cordeliers, Sorbonne Universite, Inserm, Universite de Paris, Team Integrative Cancer Immunology F-75006, Paris, France.
  • Fayol A; Sorbonne Universite, Paris, France.
  • Arlet JB; Department of Immunology, Hôpital Europeen Georges Pompidou, AP-HP, Paris, France.
  • Diehl JL; Université de Paris, Innovative Therapies in Hemostasis, INSERM, Hematology Department and Biosurgical Research Lab, (Carpentier Foundation) Assistance Publique Hôpitaux de Paris, Centre-Université de Paris (APHP-CUP), Paris, France.
  • Dragon-Durey MA; F-CRIN INNOVTE, Saint-Étienne, France.
  • Pagès F; Department of Nephrology, Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
  • Cremer I; Department of Nephrology, Universite de Paris, Paris, France.
Front Immunol ; 12: 701273, 2021.
Article in English | MEDLINE | ID: covidwho-1332121
ABSTRACT
SARS-CoV-2 infection leads to a highly variable clinical evolution, ranging from asymptomatic to severe disease with acute respiratory distress syndrome, requiring intensive care units (ICU) admission. The optimal management of hospitalized patients has become a worldwide concern and identification of immune biomarkers predictive of the clinical outcome for hospitalized patients remains a major challenge. Immunophenotyping and transcriptomic analysis of hospitalized COVID-19 patients at admission allow identifying the two categories of patients. Inflammation, high neutrophil activation, dysfunctional monocytic response and a strongly impaired adaptive immune response was observed in patients who will experience the more severe form of the disease. This observation was validated in an independent cohort of patients. Using in silico analysis on drug signature database, we identify differential therapeutics that specifically correspond to each group of patients. From this signature, we propose a score-the SARS-Score-composed of easily quantifiable biomarkers, to classify hospitalized patients upon arrival to adapt treatment according to their immune profile.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.701273

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.701273