Two newly isolated GVI lineage infectious bronchitis viruses in China show unique molecular and pathogenicity characteristics.
Infect Genet Evol
; 94: 105006, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1332841
ABSTRACT
During 2016 to 2020, GVI-1 type infectious bronchitis virus (IBV) strains were sporadically reported across China, indicating a new epidemic trend of the virus. Here we investigated the molecular characteristics and pathogenicity of two newly isolated GVI-1 type IBV virus strains (CK/CH/TJ1904 and CK/CH/NP2011) from infected chicken farms in China. Genetic evolution analysis of the S1 gene showed the highest homology with the GVI-1 representative strain, TC07-2. Phylogenetic analysis and recombination analysis of the virus genomes indicated that newly isolated strains in China may be independently derived from recombination events that occurred between GI-19 and GI-22 strains and early GVI-1 viruses. Interestingly, unlike the deduced parental GI-19 or GI-22 strains, CK/CH/TJ1904 and CK/CH/NP2011 showed affinity for the trachea rather than the kidney and were less pathogenic. This difference may be because of recombination events that occurred during the long co-existence of the GVI-1 viruses with prevalent GI-19 and GI-22 strains. Considering the new trend, it is very important to permanently monitor circulating strains and to develop new vaccines to counteract emerging new-type IBVs.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Poultry Diseases
/
Chickens
/
Coronavirus Infections
/
Infectious bronchitis virus
Type of study:
Randomized controlled trials
Topics:
Vaccines
Limits:
Animals
Country/Region as subject:
Asia
Language:
English
Journal:
Infect Genet Evol
Journal subject:
Biology
/
Communicable Diseases
/
Genetics
Year:
2021
Document Type:
Article
Affiliation country:
J.meegid.2021.105006
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