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Changes in mood and health-related quality of life in Look AHEAD 6 years after termination of the lifestyle intervention.
Wadden, Thomas A; Chao, Ariana M; Anderson, Harelda; Annis, Kirsten; Atkinson, Karen; Bolin, Paula; Brantley, Phillip; Clark, Jeanne M; Coday, Mace; Dutton, Gareth; Foreyt, John P; W Gregg, Edward; Hazuda, Helen P; Hill, James O; Hubbard, Van S; Jakicic, John M; Jeffery, Robert W; Johnson, Karen C; Kahn, Steven E; Knowler, William C; Korytkowski, Mary; Lewis, Cora E; Laferrère, Blandine; Middelbeek, Roeland J; Munshi, Medha N; Nathan, David M; Neiberg, Rebecca H; Pilla, Scott J; Peters, Anne; Pi-Sunyer, Xavier; Rejeski, Jack W; Redmon, Bruce; Stewart, Tiffany; Vaughan, Elizabeth; Wagenknecht, Lynne E; Walkup, Michael P; Wing, Rena R; Wyatt, Holly; Yanovski, Susan Z; Zhang, Ping.
  • Wadden TA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Chao AM; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Anderson H; Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, and Shiprock, New Mexico, USA.
  • Annis K; Department of Psychiatry, the Miriam Hospital, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
  • Atkinson K; Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.
  • Bolin P; Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, and Shiprock, New Mexico, USA.
  • Brantley P; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Clark JM; Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Coday M; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Dutton G; Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
  • Foreyt JP; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
  • W Gregg E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Hazuda HP; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Hill JO; Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
  • Hubbard VS; Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Jakicic JM; Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Jeffery RW; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
  • Johnson KC; Departments of Preventive Medicine and Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
  • Kahn SE; Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.
  • Knowler WC; Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, and Shiprock, New Mexico, USA.
  • Korytkowski M; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Lewis CE; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Laferrère B; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Middelbeek RJ; Joslin Diabetes Center, Boston, Massachusetts, USA.
  • Munshi MN; Joslin Diabetes Center, Boston, Massachusetts, USA.
  • Nathan DM; Diabetes Center, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts, USA.
  • Neiberg RH; Department of Biostatistics and Data Science, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Pilla SJ; Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Peters A; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Pi-Sunyer X; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Rejeski JW; Department of Health and Exercise Sciences, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Redmon B; Department of Medicine, University of Minnesota Medical School, Twin Cities, Minneapolis, Minnesota, USA.
  • Stewart T; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Vaughan E; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
  • Wagenknecht LE; Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Walkup MP; Department of Biostatistics and Data Science, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Wing RR; Department of Psychiatry, the Miriam Hospital, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
  • Wyatt H; Department of Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
  • Yanovski SZ; Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Zhang P; Centers for Disease Control and Prevention, DDT Health Economics Workgroup Atlanta, Atlanta, Georgia, USA.
Obesity (Silver Spring) ; 29(8): 1294-1308, 2021 08.
Article in English | MEDLINE | ID: covidwho-1333021
ABSTRACT

OBJECTIVE:

The Action for Health in Diabetes (Look AHEAD) study previously reported that intensive lifestyle intervention (ILI) reduced incident depressive symptoms and improved health-related quality of life (HRQOL) over nearly 10 years of intervention compared with a control group (the diabetes support and education group [DSE]) in participants with type 2 diabetes and overweight or obesity. The present study compared incident depressive symptoms and changes in HRQOL in these groups for an additional 6 years following termination of the ILI in September 2012.

METHODS:

A total of 1,945 ILI participants and 1,900 DSE participants completed at least one of four planned postintervention assessments at which weight, mood (via the Patient Health Questionnaire-9), antidepressant medication use, and HRQOL (via the Medical Outcomes Scale, Short Form-36) were measured.

RESULTS:

ILI participants and DSE participants lost 3.1 (0.3) and 3.8 (0.3) kg [represented as mean (SE); p = 0.10], respectively, during the 6-year postintervention follow-up. No significant differences were observed between groups during this time in incident mild or greater symptoms of depression, antidepressant medication use, or in changes on the physical component summary or mental component summary scores of the Short Form-36. In both groups, mental component summary scores were higher than physical component summary scores.

CONCLUSIONS:

Prior participation in the ILI, compared with the DSE group, did not appear to improve subsequent mood or HRQOL during 6 years of postintervention follow-up.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / Diabetes Mellitus, Type 2 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Obesity (Silver Spring) Journal subject: Nutritional Sciences / Physiology / Metabolism Year: 2021 Document Type: Article Affiliation country: Oby.23191

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / Diabetes Mellitus, Type 2 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Obesity (Silver Spring) Journal subject: Nutritional Sciences / Physiology / Metabolism Year: 2021 Document Type: Article Affiliation country: Oby.23191