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Antibody responses after first and second Covid-19 vaccination in patients with chronic lymphocytic leukaemia.
Parry, H; McIlroy, G; Bruton, R; Ali, M; Stephens, C; Damery, S; Otter, A; McSkeane, T; Rolfe, H; Faustini, S; Wall, N; Hillmen, P; Pratt, G; Paneesha, S; Zuo, J; Richter, A; Moss, P.
  • Parry H; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • McIlroy G; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
  • Bruton R; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Ali M; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Stephens C; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Damery S; Institute of Applied Health Research, University of Birmingham, Birmingham, B15 2TT, UK.
  • Otter A; National infection Service, Public Health England, Porton Down, Salisbury, SP4 OJG, UK.
  • McSkeane T; Cancer Research UK Clinical Trials Unit, University of Birmingham, B15 2TT, Birmingham, UK.
  • Rolfe H; Cancer Research UK Clinical Trials Unit, University of Birmingham, B15 2TT, Birmingham, UK.
  • Faustini S; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Wall N; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Hillmen P; St. James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, UK.
  • Pratt G; Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, B15 2TH, UK.
  • Paneesha S; Birmingham Heartlands Hospital, University Hospitals Birmingham, Bordesley Green East, B9 5SS, Birmingham, UK.
  • Zuo J; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Richter A; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Moss P; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK. P.moss@bham.ac.uk.
Blood Cancer J ; 11(7): 136, 2021 07 30.
Article in English | MEDLINE | ID: covidwho-1333907
ABSTRACT
B-cell chronic lymphocytic leukaemia (CLL) is associated with immunosuppression and patients are at increased clinical risk following SARS-CoV-2 infection. Covid-19 vaccines offer the potential for protection against severe infection but relatively little is known regarding the profile of the antibody response following first or second vaccination. We studied spike-specific antibody responses following first and/or second Covid-19 vaccination in 299 patients with CLL compared with healthy donors. 286 patients underwent extended interval (10-12 week) vaccination. 154 patients received the BNT162b2 mRNA vaccine and 145 patients received ChAdOx1. Blood samples were taken either by venepuncture or as dried blood spots on filter paper. Spike-specific antibody responses were detectable in 34% of patients with CLL after one vaccine (n = 267) compared to 94% in healthy donors with antibody titres 104-fold lower in the patient group. Antibody responses increased to 75% after second vaccine (n = 55), compared to 100% in healthy donors, although titres remained lower. Multivariate analysis showed that current treatment with BTK inhibitors or IgA deficiency were independently associated with failure to generate an antibody response after the second vaccine. This work supports the need for optimisation of vaccination strategy in patients with CLL including the potential utility of booster vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / Immunization, Secondary / COVID-19 Vaccines / COVID-19 / Antibodies, Viral / Antibody Formation Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Cancer J Year: 2021 Document Type: Article Affiliation country: S41408-021-00528-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / Immunization, Secondary / COVID-19 Vaccines / COVID-19 / Antibodies, Viral / Antibody Formation Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Cancer J Year: 2021 Document Type: Article Affiliation country: S41408-021-00528-x