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Lung donation following SARS-CoV-2 infection.
Querrey, Melissa; Kurihara, Chitaru; Manerikar, Adwaiy; Garza-Castillon, Rafael; Lysne, Jeffrey; Tomic, Rade; Budinger, Gr Scott; Kim, Samuel; Lung, Kalvin; Yeldandi, Anjana; Bharat, Ankit.
  • Querrey M; Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Kurihara C; Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Manerikar A; Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Garza-Castillon R; Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Lysne J; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Tomic R; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Budinger GS; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Kim S; Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Lung K; Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Yeldandi A; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Bharat A; Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Am J Transplant ; 21(12): 4073-4078, 2021 12.
Article in English | MEDLINE | ID: covidwho-1334386
ABSTRACT
There have been over 177 million cases of COVID-19 worldwide, many of whom could be organ donors. Concomitantly, there is an anticipated increase in the need for donor lungs due to expanding indications. Given that the respiratory tract is most commonly affected by COVID-19, there is an urgent need to develop donor assessment criteria while demonstrating safety and "efficacy" of lung donation following COVID-19 infection. Accordingly, we report an intentional transplant using lungs from a donor with recent, microbiologically confirmed, COVID-19 infection into a recipient suffering from COVID-19 induced ARDS and pulmonary fibrosis. In addition to the standard clinical assays, both donor and recipient lungs were analyzed using RNAscope, which confirmed that tissues were negative for SARS-CoV-2. Immunohistochemistry demonstrated colocalized KRT17+ basaloid-like epithelium and COL1A1+ fibroblasts, a marker suggestive of lung fibrosis in COVID-19 associated lung disease, in the explanted recipient lungs but absent in the donor lungs. We demonstrate that following a thorough assessment, lung donation following resolved COVID-19 infection is safe and feasible.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tissue and Organ Procurement / Lung Transplantation / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Ajt.16777

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tissue and Organ Procurement / Lung Transplantation / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Ajt.16777