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Elevated INR in a COVID-19 patient after concomitant administration of favipiravir and warfarin: A case report.
Sekimoto, Masao; Imai, Toru; Hidaka, Shinji; Chiba, Nobutaka; Sakurai, Atsushi; Hata, Mitsumasa; Kikuchi, Norikazu.
  • Sekimoto M; Department of Pharmacy, Nihon University Hospital, Tokyo, Japan.
  • Imai T; Department of Pharmacy, Nihon University Itabashi Hospital, Tokyo, Japan.
  • Hidaka S; Department of Pharmaceutical Regulatory Science, School of Pharmacy, Nihon University, Chiba, Japan.
  • Chiba N; Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan.
  • Sakurai A; Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan.
  • Hata M; Department of Cardiovascular Surgery, Nihon University Hospital, Tokyo, Japan.
  • Kikuchi N; Department of Pharmacy, Nihon University Hospital, Tokyo, Japan.
J Clin Pharm Ther ; 47(3): 407-410, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1334480
ABSTRACT
WHAT IS KNOWN AND

OBJECTIVE:

Favipiravir is a promising treatment candidate for managing coronavirus disease 2019 (COVID-19). Warfarin has many drug interactions, but no interactions with favipiravir have been reported. CASE

SUMMARY:

Our patient was taking warfarin for deep vein thrombosis. The international normalized ratio (INR) was stable (1.65 to 2.0); however, it increased to 4.63 after administering favipiravir. The patient had no other factors justifying this change. WHAT IS NEW AND

CONCLUSION:

Favipiravir and warfarin might have previously unidentified drug interactions that elevated the INR. Therefore, INR must be closely monitored when they are concomitantly administered in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Warfarin / COVID-19 Drug Treatment Type of study: Case report Limits: Humans Language: English Journal: J Clin Pharm Ther Journal subject: Pharmacy / Therapeutics Year: 2022 Document Type: Article Affiliation country: Jcpt.13499

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Warfarin / COVID-19 Drug Treatment Type of study: Case report Limits: Humans Language: English Journal: J Clin Pharm Ther Journal subject: Pharmacy / Therapeutics Year: 2022 Document Type: Article Affiliation country: Jcpt.13499