Your browser doesn't support javascript.
Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19-A Preliminary Study.
Kusnierz-Cabala, Beata; Maziarz, Barbara; Dumnicka, Paulina; Dembinski, Marcin; Kapusta, Maria; Bociaga-Jasik, Monika; Winiarski, Marek; Garlicki, Aleksander; Grodzicki, Tomasz; Kukla, Michal.
  • Kusnierz-Cabala B; Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Krakow 31-066, Poland.
  • Maziarz B; Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Krakow 31-066, Poland.
  • Dumnicka P; Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow 30-688, Poland.
  • Dembinski M; 2nd Department of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland.
  • Kapusta M; Department of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Krakow 31-066, Poland.
  • Bociaga-Jasik M; Hepatology and Infectious Diseases, Chair of Gastroenterology, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland.
  • Winiarski M; 2nd Department of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland.
  • Garlicki A; Hepatology and Infectious Diseases, Chair of Gastroenterology, Faculty of Medicine, Jagiellonian University Medical College, Krakow 30-688, Poland.
  • Grodzicki T; Department of Internal Medicine and Geriatrics, Faculty of Medicine, Jagiellonian University Medical College, Kraków 30-688, Poland.
  • Kukla M; Department of Internal Medicine and Geriatrics, Faculty of Medicine, Jagiellonian University Medical College, Kraków 30-688, Poland.
Biomolecules ; 11(8)2021 08 01.
Article in English | MEDLINE | ID: covidwho-1334994
ABSTRACT
Severe coronavirus disease 2019 (COVID-19) is associated with hyperinflammation leading to organ injury, including respiratory failure. Galectin-3 was implicated in innate immunological response to infections and in chronic fibrosis. The aim of our preliminary study was the assessment of the diagnostic utility of serum galectin-3 in patients with COVID-19. The prospective observational study included adult patients admitted with active COVID-19 and treated in tertiary hospital between June and July 2020. The diagnosis was confirmed by the quantitative detection of nucleic acid of severe acute respiratory syndrome coronavirus 2 in nasopharyngeal swabs. Galectin-3 was measured by enzyme immunoassay in serum samples obtained during the first five days of hospital stay. We included 70 patients aged 25 to 73 years; 90% had at least one comorbidity. During the hospital stay, 32.9% were diagnosed with COVID-19 pneumonia and 12.9% required treatment in the intensive care unit (ICU). Serum galectin-3 was significantly increased in patients who developed pneumonia, particularly those who required ICU admission. Positive correlations were found between galectin-3 and inflammatory markers (interleukin-6, C-reactive protein, ferritin, pentraxin-3), a marker of endothelial injury (soluble fms-like tyrosine kinase-1), and a range of tissue injury markers. Serum galectin-3 enabled the diagnosis of pneumonia with moderate diagnostic accuracy and the need for ICU treatment with high diagnostic accuracy. Our findings strengthen the hypothesis that galectin-3 may be involved in severe COVID-19. Further studies are planned to confirm the preliminary results and to verify possible associations of galectin-3 with long-term consequences of COVID-19, including pulmonary fibrosis.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Galectin 3 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Biom11081136

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Galectin 3 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Biom11081136