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The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection.
Conceição-Silva, Fátima; Reis, Clarissa S M; De Luca, Paula Mello; Leite-Silva, Jessica; Santiago, Marta A; Morrot, Alexandre; Morgado, Fernanda N.
  • Conceição-Silva F; Laboratory of Immunoparasitology, Oswaldo Cruz Institute (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21.040-360, RJ, Brazil.
  • Reis CSM; Laboratory of Immunoparasitology, Oswaldo Cruz Institute (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21.040-360, RJ, Brazil.
  • De Luca PM; Postgraduate Program in Clinical Research in Infectious Diseases, INI-Fiocruz, Rio de Janeiro 21.040-360, RJ, Brazil.
  • Leite-Silva J; Laboratory of Immunoparasitology, Oswaldo Cruz Institute (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21.040-360, RJ, Brazil.
  • Santiago MA; Laboratory of Immunoparasitology, Oswaldo Cruz Institute (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21.040-360, RJ, Brazil.
  • Morrot A; Postgraduate Program in Parasitic Biology, IOC-Fiocruz, Rio de Janeiro 21.040-360, RJ, Brazil.
  • Morgado FN; Laboratory of Immunoparasitology, Oswaldo Cruz Institute (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21.040-360, RJ, Brazil.
Cells ; 10(8)2021 07 26.
Article in English | MEDLINE | ID: covidwho-1335011
ABSTRACT
The first formal description of the microbicidal activity of extracellular traps (ETs) containing DNA occurred in neutrophils in 2004. Since then, ETs have been identified in different populations of cells involved in both innate and adaptive immune responses. Much of the knowledge has been obtained from in vitro or ex vivo studies; however, in vivo evaluations in experimental models and human biological materials have corroborated some of the results obtained. Two types of ETs have been described-suicidal and vital ETs, with or without the death of the producer cell. The studies showed that the same cell type may have more than one ETs formation mechanism and that different cells may have similar ETs formation mechanisms. ETs can act by controlling or promoting the mechanisms involved in the development and evolution of various infectious and non-infectious diseases, such as autoimmune, cardiovascular, thrombotic, and neoplastic diseases, among others. This review discusses the presence of ETs in neutrophils, macrophages, mast cells, eosinophils, basophils, plasmacytoid dendritic cells, and recent evidence of the presence of ETs in B lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes. Moreover, due to recently collected information, the effect of ETs on COVID-19 is also discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps Type of study: Experimental Studies Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10081891

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracellular Traps Type of study: Experimental Studies Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10081891