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Calprotectin and SARS-CoV-2: A Brief-Report of the Current Literature.
Giuffrè, Mauro; Vetrugno, Luigi; Di Bella, Stefano; Moretti, Rita; Berretti, Debora; Crocè, Lory Saveria.
  • Giuffrè M; Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.
  • Vetrugno L; Italian Liver Foundation, 34149 Trieste, Italy.
  • Di Bella S; Department of Medicine, Anesthesia and Intensive Care Clinic, University of Udine, 33100 Udine, Italy.
  • Moretti R; Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.
  • Berretti D; Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.
  • Crocè LS; Debora Berretti-Gastroenterology Unit, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.
Healthcare (Basel) ; 9(8)2021 Jul 29.
Article in English | MEDLINE | ID: covidwho-1335032
ABSTRACT
In late December 2019, a novel coronavirus (lately referred to as SARS-CoV-2) spread in the city of Wuhan, China, causing an outbreak of unusual viral pneumonia. In many people, the disease is mild and self-limiting, but in a considerable number of patients, the disease may present more severe or even fatal. Therefore, determining which patients are at higher risk of developing a more severe disease is critical. Some studies have been focused on serum and fecal calprotectin to evaluate COVID-19 disease progression and possible complications. Some assumptions can be made (1) serum calprotectin may efficiently predict the prognosis of COVID-19 patients; (2) fecal calprotectin may appear high in COVID-19 patients due to the double hit mechanism to the intestine (inflammatory and ischemic); (3) a relationship between the complement system and neutrophil activation contributes to the procoagulant status seen in COVID-19 patients; (4) some patients may develop severe gastro-intestinal complications and fecal calprotectin can be used to monitor intestinal disease activity levels.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Healthcare9080956

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Healthcare9080956