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Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection.
Frustaci, Andrea; Francone, Marco; Verardo, Romina; Capobianchi, Maria Rosaria; Chimenti, Cristina.
  • Frustaci A; Department of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00166 Rome, Italy.
  • Francone M; Department of Radiological, Oncological and Pathological Sciences, Sapienza University, 00166 Rome, Italy.
  • Verardo R; Cellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, 00149 Rome, Italy.
  • Capobianchi MR; Laboratory of Virology National Institute for Infectious Diseases "L. Spallanzani", 00149 Rome, Italy.
  • Chimenti C; Laboratory of Virology National Institute for Infectious Diseases "L. Spallanzani", 00149 Rome, Italy.
Infect Dis Rep ; 13(3): 597-601, 2021 Jun 24.
Article in English | MEDLINE | ID: covidwho-1335035
ABSTRACT
We report a case of myopericarditis associated to SARS-CoV-2 infection with necrotizing coronary vasculitis of intramural vessels, giving rise to biventricular apical microaneurysms and to electrical instability. Negativity of myocardial polymerase chain reaction for the most common cardiotropic viruses and for SARS-CoV-2 suggested an immune-mediated myocardial and pericardial inflammatory disease. High dose (1 mg/Kg daily) prednisone and anti-viral (Remdesivir, IDA Business, Carrigtohill, County Cork, T45 DP77, Ireland) therapy led to resolution of cardiac inflammation and ventricular arrhythmias. Morpho-molecular characterization of endomyocardial tissue may improve the outcome in subjects with SARS-CoV-2-associated myopericarditis and coronary vasculitis.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Infect Dis Rep Year: 2021 Document Type: Article Affiliation country: IDR13030055

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Infect Dis Rep Year: 2021 Document Type: Article Affiliation country: IDR13030055