Your browser doesn't support javascript.
Exploring Pregnancy Outcomes Associated with SARS-CoV-2 Infection.
Timircan, Madalina; Bratosin, Felix; Vidican, Iulia; Suciu, Oana; Tirnea, Livius; Avram, Valentina; Marincu, Iosif.
  • Timircan M; Department of Gynecology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Bratosin F; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Vidican I; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Suciu O; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Tirnea L; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Avram V; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
  • Marincu I; Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Medicina (Kaunas) ; 57(8)2021 Aug 01.
Article in English | MEDLINE | ID: covidwho-1335150
ABSTRACT
Background and

Objectives:

The ongoing pandemic proved to be a tremendous challenge to all economic layers, healthcare, and people safety. As more than one year elapsed since the beginning of the COVID-19 pandemic, a multitude of medical studies involving the SARS-CoV-2 virus helped researchers and medical practitioners in understanding the effects it has on all sorts of patients until effective vaccines were finally developed and distributed for mass vaccination. Still, the SARS-CoV-2 and its new variants remain a potential threat towards all categories of patients, including a more delicate group represented by pregnant women. Thus, the current study aims to investigate the potential effects on obstetrical outcomes after a positive SARS-CoV-2 infection. Materials and

Methods:

This single-center prospective cohort study investigated the pregnancy outcomes in a total of 1039 eligible pregnant women between 30 August 2020 and 30 January 2021. Multiple patient characteristics and obstetrical outcomes were tested and analyzed in a multivariate regression model to establish potential risks determined by a COVID-19-positive pregnancy towards the mother and the newborn.

Results:

In the study sample, there were 938 pregnancies included without COVID-19 and 101 pregnant women identified with a positive COVID-19 infection. COVID-19 was significantly associated with a 2-fold increase in the risk of premature rupture of membranes and 1.5 times higher risk of preterm birth with emergency c-sections and lower APGAR scores. Also, significantly more newborns were given birth prematurely, with lower APGAR scores after the mothers were infected with SARS-CoV-2.

Conclusions:

A third-trimester infection with SARS-CoV-2 is a significant risk factor for preterm birth via an emergency cesarean section, a premature rupture of membranes, and a lower APGAR score in newborns, as compared with pregnancies where COVID-19 was not identified.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Premature Birth / COVID-19 Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Medicina57080796

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Premature Birth / COVID-19 Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Medicina57080796