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Severe SARS-CoV-2 Infection in a Cat with Hypertrophic Cardiomyopathy.
Carvallo, Francisco R; Martins, Mathias; Joshi, Lok R; Caserta, Leonardo C; Mitchell, Patrick K; Cecere, Thomas; Hancock, Sandy; Goodrich, Erin L; Murphy, Julia; Diel, Diego G.
  • Carvallo FR; Department of Biomedical Sciences & Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
  • Martins M; Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, 240 Farrier Rd., AHDC A3-114, Ithaca, NY 14853, USA.
  • Joshi LR; Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, 240 Farrier Rd., AHDC A3-114, Ithaca, NY 14853, USA.
  • Caserta LC; Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, 240 Farrier Rd., AHDC A3-114, Ithaca, NY 14853, USA.
  • Mitchell PK; Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, 240 Farrier Rd., AHDC A3-114, Ithaca, NY 14853, USA.
  • Cecere T; Department of Biomedical Sciences & Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
  • Hancock S; Laboratory for Neurotoxicity Studies, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
  • Goodrich EL; Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, 240 Farrier Rd., AHDC A3-114, Ithaca, NY 14853, USA.
  • Murphy J; Virginia Department of Health, Division of Surveillance and Investigation, Richmond, VA 23218, USA.
  • Diel DG; Animal Health Diagnostic Center, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, 240 Farrier Rd., AHDC A3-114, Ithaca, NY 14853, USA.
Viruses ; 13(8)2021 07 31.
Article in English | MEDLINE | ID: covidwho-1335235
ABSTRACT
Coronavirus disease 19 (COVID-19), has claimed millions of human lives worldwide since the emergence of the zoonotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in December 2019. Notably, most severe and fatal SARS-CoV-2 infections in humans have been associated with underlying clinical conditions, including diabetes, hypertension and heart diseases. Here, we describe a case of severe SARS-CoV-2 infection in a domestic cat (Felis catus) that presented with hypertrophic cardiomyopathy (HCM), a chronic heart condition that has been described as a comorbidity of COVID-19 in humans and that is prevalent in domestic cats. The lung and heart of the affected cat presented clear evidence of SARS-CoV-2 replication, with histological lesions similar to those observed in humans with COVID-19 with high infectious viral loads being recovered from these organs. The study highlights the potential impact of comorbidities on the outcome of SARS-CoV-2 infection in animals and provides important information that may contribute to the development of a feline model with the potential to recapitulate the clinical outcomes of severe COVID-19 in humans.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: V13081510

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: V13081510