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Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy.
Castelli, Matteo; Baj, Andreina; Criscuolo, Elena; Ferrarese, Roberto; Diotti, Roberta A; Sampaolo, Michela; Novazzi, Federica; Dalla Gasperina, Daniela; Focosi, Daniele; Ferrari, Davide; Locatelli, Massimo; Clementi, Massimo; Clementi, Nicola; Maggi, Fabrizio; Mancini, Nicasio.
  • Castelli M; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
  • Baj A; Laboratory of Microbiology, ASST Sette Laghi, 21100 Varese, Italy.
  • Criscuolo E; Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
  • Ferrarese R; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
  • Diotti RA; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
  • Sampaolo M; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
  • Novazzi F; Laboratory of Microbiology and Virology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.
  • Dalla Gasperina D; Laboratory of Microbiology, ASST Sette Laghi, 21100 Varese, Italy.
  • Focosi D; Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
  • Ferrari D; Internal Medicine Unit, ASST Sette Laghi, 21100 Varese, Italy.
  • Locatelli M; North-Western Tuscany Blood Bank, Pisa University Hospital, 56127 Pisa, Italy.
  • Clementi M; SCVSA Department, University of Parma, 43121 Parma, Italy.
  • Clementi N; Laboratory Medicine Service, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Maggi F; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
  • Mancini N; Laboratory of Microbiology and Virology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.
Viruses ; 13(8)2021 07 31.
Article in English | MEDLINE | ID: covidwho-1335236
ABSTRACT
SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13081514

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Topics: Vaccines Limits: Humans Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13081514