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Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia.
Ott, Ashley; Venkataraman, Vinayak; Badran, Yousef R; Goldman, Rose; Spasic, Smiljana; Vyas, Darshali A; Amrein, Philip; McAfee, Steven; Brunner, Andrew; Fathi, Amir T; Narayan, Rupa.
  • Ott A; Department of Medicine Massachusetts General Hospital Boston MA USA.
  • Venkataraman V; Department of Medicine Massachusetts General Hospital Boston MA USA.
  • Badran YR; Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA.
  • Goldman R; Department of Environmental Health Harvard T.H. Chan School of Public Health Boston MA USA.
  • Spasic S; Department of Medicine Cambridge Health Alliance Boston MA USA.
  • Vyas DA; Department of Pathology Massachusetts General Hospital Boston MA USA.
  • Amrein P; Department of Medicine Massachusetts General Hospital Boston MA USA.
  • McAfee S; Division of Hematology/Oncology Massachusetts General Hospital Boston MA USA.
  • Brunner A; Division of Hematology/Oncology Massachusetts General Hospital Boston MA USA.
  • Fathi AT; Division of Hematology/Oncology Massachusetts General Hospital Boston MA USA.
  • Narayan R; Division of Hematology/Oncology Massachusetts General Hospital Boston MA USA.
Clin Case Rep ; 9(5): e04115, 2021 May.
Article in English | MEDLINE | ID: covidwho-1335986
ABSTRACT
Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Experimental Studies Language: English Journal: Clin Case Rep Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Experimental Studies Language: English Journal: Clin Case Rep Year: 2021 Document Type: Article