Immune evasion of SARS-CoV-2 from interferon antiviral system.
Comput Struct Biotechnol J
; 19: 4217-4225, 2021.
Article
in English
| MEDLINE | ID: covidwho-2272232
ABSTRACT
The on-going pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented medical and socioeconomic crises. Although the viral pathogenesis remains elusive, deficiency of effective antiviral interferon (IFN) responses upon SARS-CoV-2 infection has been recognized as a hallmark of COVID-19 contributing to the disease pathology and progress. Recently, multiple proteins encoded by SARS-CoV-2 have been shown to act as potential IFN antagonists with diverse possible mechanisms. Here, we summarize and discuss the strategies of SARS-CoV-2 for evasion of innate immunity (particularly the antiviral IFN responses), understanding of which will facilitate not only the elucidation of SARS-CoV-2 infection and pathogenesis but also the development of antiviral intervention therapies.
Full text:
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Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Comput Struct Biotechnol J
Year:
2021
Document Type:
Article
Affiliation country:
J.csbj.2021.07.023
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