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Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model.
Blake, Steven; Shaabani, Namir; Eubanks, Lisa M; Maruyama, Junki; Manning, John T; Beutler, Nathan; Paessler, Slobodan; Ji, Henry; Teijaro, John R; Janda, Kim D.
  • Blake S; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Shaabani N; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Eubanks LM; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Maruyama J; Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, United States.
  • Manning JT; Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, United States.
  • Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Paessler S; Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, United States.
  • Ji H; Sorrento Therapeutics Inc., 4955 Directors Place, San Diego, California 92121, United States.
  • Teijaro JR; Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Janda KD; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
ACS Infect Dis ; 7(8): 2229-2237, 2021 08 13.
Article in English | MEDLINE | ID: covidwho-1337099
ABSTRACT
SARS-CoV-2 virus has recently given rise to the current COVID-19 pandemic where infected individuals can range from being asymptomatic, yet highly contagious, to dying from acute respiratory distress syndrome. Although the world has mobilized to create antiviral vaccines and therapeutics to combat the scourge, their long-term efficacy remains in question especially with the emergence of new variants. In this work, we exploit a class of compounds that has previously shown success against various viruses. A salicylanilide library was first screened in a SARS-CoV-2 activity assay in Vero cells. The most efficacious derivative was further evaluated in a prophylactic mouse model of SARS-CoV-2 infection unveiling a salicylanilide that can reduce viral loads, modulate key cytokines, and mitigate severe weight loss involved in COVID-19 infections. The combination of anti-SARS-CoV-2 activity, cytokine inhibitory activity, and a previously established favorable pharmacokinetic profile for the lead salicylanilide renders salicylanilides in general as promising therapeutics for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: ACS Infect Dis Year: 2021 Document Type: Article Affiliation country: Acsinfecdis.1c00253

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: ACS Infect Dis Year: 2021 Document Type: Article Affiliation country: Acsinfecdis.1c00253