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Association of depression with il-6 and crp levels among covid recovered patients: A hospital based case control study
International Journal of Toxicological and Pharmacological Research ; 11(2):23-27, 2021.
Article in English | EMBASE | ID: covidwho-1338034
ABSTRACT

Introduction:

Depression has been reported in patients suffered from COVID 19 (corona virus disease). Inflammatory markers like IL-6 and CRP have been also found raised in COVID 19 patients.

Aim:

The objective of present study was to find out the association of serum IL-6 and CRP levels with depression in COVID 19 patients discharged from hospital. Materials and

Methodology:

This Case control study included 30 patients of depression attending post COVID OPD after getting discharged from hospital and 30 post COVID patients without depression. Depression was diagnosed using PHQ-9 scores. A cutoff value of 10 was taken to diagnose depression upon PHQ-9 scale. Both groups were compared in relation to socio-demographic variables, serum IL-6 & CRP levels and other clinical variables.

Results:

Serum IL-6 and CRP levels were significantly higher in post COVID patients with depression (IL-6=39.71 ± 46.39, CRP=43.66 ± 31.78) than those without depression (IL-6= 13.42 ± 18.98, CRP= 21.02 ± 25.36). Hospital stay was also greater in post COVID patients with depression.

Conclusion:

Post COVID depression was significantly associated with IL-6 and CRP levels. Patients with raised level of these markers could be screened for early identification of depression and counseled preferentially for prevention of depression during post COVID period.
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Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Language: English Journal: International Journal of Toxicological and Pharmacological Research Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Language: English Journal: International Journal of Toxicological and Pharmacological Research Year: 2021 Document Type: Article