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Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids.
Chen, Kevin G; Park, Kyeyoon; Spence, Jason R.
  • Chen KG; NIH Stem Cell Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. cheng@mail.nih.gov.
  • Park K; NIH Stem Cell Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Spence JR; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Nat Cell Biol ; 23(8): 822-833, 2021 08.
Article in English | MEDLINE | ID: covidwho-1338539
ABSTRACT
Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organoids / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Nat Cell Biol Year: 2021 Document Type: Article Affiliation country: S41556-021-00721-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organoids / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Nat Cell Biol Year: 2021 Document Type: Article Affiliation country: S41556-021-00721-x