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Impact of a two-dose varicella immunization program on the incidence of varicella: a multi-year observational study in Shanghai, China.
Li, Zhi; Yao, Ye; Lu, Xinyue; Liu, Jiechen; Huang, Zhuoying; Sun, Xiaodong; Lu, Yihan.
  • Li Z; Division Of Immunization, Shanghai Municipal Center For Disease Control And Prevention, Shanghai China.
  • Yao Y; Department Of Biostatistics, Ministry Of Education Key Laboratory Of Public Health Safety, School Of Public Health, Fudan University, Shanghai, China.
  • Lu X; Department Of Epidemiology, Ministry Of Education Key Laboratory Of Public Health Safety, School Of Public Health, Fudan University, Shanghai China.
  • Liu J; Division Of Immunization, Shanghai Municipal Center For Disease Control And Prevention, Shanghai China.
  • Huang Z; Division Of Immunization, Shanghai Municipal Center For Disease Control And Prevention, Shanghai China.
  • Sun X; Division Of Immunization, Shanghai Municipal Center For Disease Control And Prevention, Shanghai China.
  • Lu Y; Department Of Epidemiology, Ministry Of Education Key Laboratory Of Public Health Safety, School Of Public Health, Fudan University, Shanghai China.
Expert Rev Vaccines ; 20(9): 1177-1183, 2021 09.
Article in English | MEDLINE | ID: covidwho-1338598
ABSTRACT

BACKGROUND:

It remains hesitant to include a two-dose varicella vaccine (VarV) in a national routine immunization program in China. We aimed to quantify the impact of the two-dose VarV on varicella incidence in Shanghai. RESEARCH DESIGN AND

METHODS:

We directly extracted the data of varicella cases and VarV doses in 2013-2020 in Shanghai, and then estimated the effects of two-dose VarV using a Serfling model.

RESULTS:

A two-dose VarV immunization program has been extensively implemented since October 2017 and become free since August 2018 in Shanghai. Before and after this program, varicella cases significantly declined in children (P < 0.01), whereas did not in adults aged >18 years (P = 0.22). Compared to the predicted number of varicella cases, actual number was significantly lower by 8% in 2018 and 28% in 2019. Among children aged 4-6 years, the reduction in varicella cases was largest. Moreover, there was a significant reduction in varicella cases throughout 2020 (P < 0.001), in which the decrease due to social distancing for the COVID-19 was 54%.

CONCLUSIONS:

A two-dose VarV immunization program may further reduce approximately one-third of varicella cases in Shanghai. Children <4 years and adults benefit less in this program, which warrants enhancing the immunization.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chickenpox / Mass Vaccination / Vaccination / Chickenpox Vaccine Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Child / Child, preschool / Humans Country/Region as subject: Asia Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chickenpox / Mass Vaccination / Vaccination / Chickenpox Vaccine Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Child / Child, preschool / Humans Country/Region as subject: Asia Language: English Journal: Expert Rev Vaccines Journal subject: Allergy and Immunology Year: 2021 Document Type: Article