Retinal nerve fibre layer and ganglion cell layer changes in children who recovered from COVID-19: a cohort study.
Arch Dis Child
; 107(2): 175-179, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1338847
ABSTRACT
OBJECTIVE:
To investigate the optic nerve and macular parameters of children who recovered from COVID-19 compared with healthy children using optical coherence tomography (OCT).DESIGN:
Cohort study.SETTING:
Hospital Clinico San Carlos, Madrid. PATIENTS Children between 6 and 18 years old who recovered from COVID-19 with laboratory-confirmed SARS-CoV-2 infection and historical controls were included.INTERVENTIONS:
All patients underwent an ophthalmological examination, including macular and optic nerve OCT. Demographic data, medical history and COVID-19 symptoms were noted. MAIN OUTCOMEMEASURES:
Peripapillary retinal nerve fibre layer thickness, macular retinal nerve fibre layer thickness, macular ganglion cell layer thickness and retinal thickness.RESULTS:
90 patients were included 29 children who recovered from COVID-19 and 61 controls. Patients with COVID-19 presented an increase in global peripapillary retinal nerve fibre layer thickness (mean difference 7.7; 95% CI 3.4 to 12.1), temporal superior (mean difference 11.0; 95% CI 3.3 to 18.6), temporal inferior (mean difference 15.6; 95% CI 6.5 to 24.7) and nasal (mean difference 9.8; 95% CI 2.9 to 16.7) sectors. Macular retinal nerve fibre layer analysis showed decreased thickness in the nasal outer (p=0.011) and temporal inner (p=0.036) sectors in patients with COVID-19, while macular ganglion cell layer thickness increased in these sectors (p=0.001 and p=0.015, respectively). No differences in retinal thickness were noted.CONCLUSIONS:
Children with recent history of COVID-19 present significant changes in peripapillary and macular OCT analyses.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Optic Nerve
/
Retinal Ganglion Cells
/
COVID-19
/
Nerve Fibers
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adolescent
/
Child
/
Humans
/
Male
Language:
English
Journal:
Arch Dis Child
Year:
2022
Document Type:
Article
Affiliation country:
Archdischild-2021-321803
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