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Impact of public health measures on the post-COVID-19 respiratory syncytial virus epidemics in France.
Fourgeaud, Jacques; Toubiana, Julie; Chappuy, Hélène; Delacourt, Christophe; Moulin, Florence; Parize, Perrine; Scemla, Anne; Abid, Hanene; Leruez-Ville, Marianne; Frange, Pierre.
  • Fourgeaud J; Laboratoire de Microbiologie Clinique, Hopital Necker - Enfants Malades, Groupe Hospitalier Assistance Publique - Hôpitaux de Paris (AP-HP) Centre, Université de Paris, 149 rue de Sèvres, 75015, Paris, France.
  • Toubiana J; EHU 7327, Institut Imagine, Université de Paris, Paris, France.
  • Chappuy H; CNR Cytomegalovirus, Laboratoire Associé, Hôpital Necker-Enfants Malades, Paris, France.
  • Delacourt C; Service de Pédiatrie Générale et Maladies Infectieuses, Hôpital Necker - Enfants Malades, Groupe Hospitalier AP-HP Centre - Université de Paris, Université de Paris, Paris, France.
  • Moulin F; CNR de la Coqueluche et autres Bordetelloses, Unité "Biodiversité et Épidémiologie des Bactéries Pathogènes", Institut Pasteur, Paris, France.
  • Parize P; Service d'Urgences Pédiatriques, Hôpital Necker - Enfants Malades, Groupe Hospitalier AP-HP Centre, Université de Paris, Paris, France.
  • Scemla A; EA7323, Université de Paris, Paris, France.
  • Abid H; Service de Pneumologie et Allergologie Pédiatriques, Hôpital Necker - Enfants Malades, Groupe Hospitalier AP-HP Centre, Université de Paris, Paris, France.
  • Leruez-Ville M; Service de Réanimation et Surveillance Continue Médico-Chirurgicale Pédiatrique, Hôpital Necker - Enfants Malades, Groupe Hospitalier AP-HP Centre, Université de Paris, Paris, France.
  • Frange P; Service de Maladies Infectieuses et Tropicales, Hôpital Necker - Enfants Malades, Groupe Hospitalier AP-HP Centre, Université de Paris, Paris, France.
Eur J Clin Microbiol Infect Dis ; 40(11): 2389-2395, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1340466
ABSTRACT
Since the beginning of the COVID-19 pandemic, other respiratory illnesses decreased worldwide. This study described the consequences of public health measures on respiratory syncytial virus (RSV) severe infections in France, where an interseasonal resurgence of RSV occurred recently. All patients admitted to Necker Hospital (Paris) between August 2018 and April 2021 with a diagnosis of RSV-associated acute lung respiratory infection (ALRI) were enrolled. Characteristics of subjects with RSV-associated ALRI in 2020/2021 were compared to those infected during the two previous outbreaks. Overall, 664 inpatients were diagnosed with RSV-associated ALRI 229, 183, and 252 during the 2018/2019, 2019/2020, and 2020/2021 outbreaks, respectively. During autumn 2020, a national lockdown began in France but schools remained open. A 3-month delayed RSV epidemic occurred at the end of this lockdown. Compared to previous outbreaks, the 2020/2021 epidemics involved more children aged 6 to 11 months (25.8% versus 13.1%, p < 0.0001), but less infants aged < 6 months (41.3% versus 56.6%, p < 0.0001) and less adults (0.0 versus 2.7%, p < 0.0001). Shorter length of stay at hospital, less frequent requirement of admission to intensive care unit, use of non-invasive ventilation, and/or high-flow nasal oxygen were observed in 2020/2021 than during previous epidemics (p < 0.0001). Delayed RSV outbreak was associated with more hospitalizations for ALRI, higher age of pediatric inpatients, but milder median clinical phenotype. Reinforced public health measures (even while keeping nurseries and schools open with mandatory face masks since six years of age) could impact, at least transiently, the burden of RSV-related hospitalizations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Public Health / Respiratory Syncytial Virus Infections / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: Europa Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: S10096-021-04323-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Public Health / Respiratory Syncytial Virus Infections / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: Europa Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: S10096-021-04323-1