Lifestyle-mediated nitric oxide boost to prevent SARS-CoV-2 infection: A perspective.
Nitric Oxide
; 115: 55-61, 2021 10 01.
Article
in English
| MEDLINE | ID: covidwho-1340778
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide and has seriously threatened public health by causing significant morbidity and mortality. Patients with coronavirus disease (COVID-19) with preexisting endothelial dysfunction caused by aging, diabetes, hypertension, and obesity are at high risk for life-threatening thromboembolic complications. This suggests a possibility that reduced endothelial nitric oxide (NO) production and NO bioavailability could be a common underlying pathology for the progression of COVID-19. Increasingly, evidence from experimental and clinical studies of SARS-CoV-2 infection shows that NO inhibits the pathogenesis of COVID-19, including virus entry into host cells, viral replication, host immune response, and subsequent thromboembolic complications. Restoring NO bioavailability may have the potential to be a preventive or early-treatment option for COVID-19. This review aims to provide in-depth discussion of NO bioavailability to prevent SARS-CoV-2 infection, particularly by focusing on lifestyle factors such as nitrate-rich diets, physical exercise, and nasal breathing, which could be easily performed on a daily basis to boost NO bioavailability.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Life Style
/
Nitric Oxide
Type of study:
Prognostic study
/
Qualitative research
Limits:
Humans
Language:
English
Journal:
Nitric Oxide
Journal subject:
Biochemistry
/
Chemistry
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS