SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses.

Zhu, Yuanmei; Yu, Danwei; Hu, Yue; Wu, Tong; Chong, Huihui; He, Yuxian

Zhu, Yuanmei; Yu, Danwei; Hu, Yue; Wu, Tong; Chong, Huihui; He, Yuxian.

Zhu Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu D; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hu Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wu T; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chong H; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
He Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. yhe@ipb.pumc.edu.cn.

Signal Transduct Target Ther ; 6(1): 294, 2021 08 03.

Article in English | MEDLINE | ID: covidwho-1340994

Subject(s)

Antiviral Agents; COVID-19 Drug Treatment; COVID-19/metabolism; Coronavirus Infections/drug therapy; Lipopeptides; Middle East Respiratory Syndrome Coronavirus; SARS-CoV-2; Virus Internalization/drug effects; Antiviral Agents/chemistry; Antiviral Agents/pharmacology; Coronavirus Infections/metabolism; Humans; Lipopeptides/chemistry; Lipopeptides/pharmacology; Middle East Respiratory Syndrome Coronavirus/chemistry; Middle East Respiratory Syndrome Coronavirus/metabolism; SARS-CoV-2/chemistry; SARS-CoV-2/metabolism

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Coronavirus Infections / Virus Internalization / Lipopeptides / Middle East Respiratory Syndrome Coronavirus / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Signal Transduct Target Ther Year: 2021 Document Type: Article Affiliation country: S41392-021-00698-x

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