Your browser doesn't support javascript.
Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury.
Obermayer, Astrid; Jakob, Lisa-Maria; Haslbauer, Jasmin D; Matter, Matthias S; Tzankov, Alexandar; Stoiber, Walter.
  • Obermayer A; Department of Biosciences, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
  • Jakob LM; Department of Biosciences, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
  • Haslbauer JD; Institute of Pathology and Medical Genetics, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland.
  • Matter MS; Institute of Pathology and Medical Genetics, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland.
  • Tzankov A; Institute of Pathology and Medical Genetics, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland.
  • Stoiber W; Department of Biosciences, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
Dis Markers ; 2021: 5566826, 2021.
Article in English | MEDLINE | ID: covidwho-1341351
ABSTRACT
An excess formation of neutrophil extracellular traps (NETs), previously shown to be strongly associated with cytokine storm and acute respiratory distress syndrome (ARDS) with prevalent endothelial dysfunction and thrombosis, has been postulated to be a central factor influencing the pathophysiology and clinical presentation of severe COVID-19. A growing number of serological and morphological evidence has added to this assumption, also in regard to potential treatment options. In this study, we used immunohistochemistry and histochemistry to trace NETs and their molecular markers in autopsy lung tissue from seven COVID-19 patients. Quantification of key immunomorphological features enabled comparison with non-COVID-19 diffuse alveolar damage. Our results strengthen and extend recent findings, confirming that NETs are abundantly present in seriously damaged COVID-19 lung tissue, especially in association with microthrombi of the alveolar capillaries. In addition, we provide evidence that low-density neutrophils (LDNs), which are especially prone to NETosis, contribute substantially to COVID-19-associated lung damage in general and vascular blockages in particular.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Injury / Extracellular Traps / COVID-19 / Neutrophils Type of study: Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Dis Markers Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: 2021

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Injury / Extracellular Traps / COVID-19 / Neutrophils Type of study: Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Dis Markers Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: 2021