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A Systematic Review of Characteristics Associated with COVID-19 in Children with Typical Presentation and with Multisystem Inflammatory Syndrome.
Kornitzer, Jeffrey; Johnson, Jacklyn; Yang, Max; Pecor, Keith W; Cohen, Nicholas; Jiang, Carolyn; Ming, Xue.
  • Kornitzer J; Division of Neurology, New Jersey Pediatric Neuroscience Institute (NJPNI), Morristown, NJ 07960, USA.
  • Johnson J; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
  • Yang M; Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
  • Pecor KW; College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Cohen N; Department of Biology, The College of New Jersey, Ewing, NJ 08628, USA.
  • Jiang C; College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Ming X; School of Arts and Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Int J Environ Res Public Health ; 18(16)2021 Aug 04.
Article in English | MEDLINE | ID: covidwho-1341688
ABSTRACT
Setting off a global pandemic, coronavirus disease 2019 (COVID-19) has been marked by a heterogeneous clinical presentation that runs the gamut from asymptomatic to severe and fatal. Although less lethal in children than adults, COVID-19 has nonetheless afflicted the pediatric population. This systematic review used clinical information from published literature to assess the spectrum of COVID-19 presentation in children, with special emphasis on characteristics associated with multisystem inflammatory syndrome (MIS-C). An electronic literature search for English and Chinese language articles in COVIDSeer, MEDLINE, and PubMed from 1 January 2020 through 1 March 2021 returned 579 records, of which 54 were included for full evaluation. Out of the total 4811 patients, 543 (11.29%) exhibited MIS-C. The most common symptoms across all children were fever and sore throat. Children presenting with MIS-C were less likely to exhibit sore throat and respiratory symptoms (i.e., cough, shortness of breath) compared to children without MIS-C. Inflammatory (e.g., rash, fever, and weakness) and gastrointestinal (e.g., nausea/vomiting and diarrhea) symptoms were present to a greater extent in children with both COVID-19 and MIS-C, suggesting that children testing positive for COVID-19 and exhibiting such symptoms should be evaluated for MIS-C.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Child / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijerph18168269

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Child / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijerph18168269