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Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality.
Palacios, Yadira; Ruiz, Andy; Ramón-Luing, Lucero A; Ocaña-Guzman, Ranferi; Barreto-Rodriguez, Omar; Sánchez-Monciváis, Anahí; Tecuatzi-Cadena, Brenda; Regalado-García, Ana G; Pineda-Gudiño, Rey David; García-Martínez, Alicia; Juárez-Hernández, Fortunato; Farias-Contreras, Juan Pablo; Fricke-Galindo, Ingrid; Pérez-Rubio, Gloria; Falfán-Valencia, Ramcés; Buendia-Roldan, Ivette; Medina-Quero, Karen; Chavez-Galan, Leslie.
  • Palacios Y; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Ruiz A; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Ramón-Luing LA; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Ocaña-Guzman R; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Barreto-Rodriguez O; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Sánchez-Monciváis A; Laboratorio de Inmunología, Escuela Militar de Graduados de Sanidad, SEDENA, Mexico City 11200, Mexico.
  • Tecuatzi-Cadena B; Laboratorio de Inmunología, Escuela Militar de Graduados de Sanidad, SEDENA, Mexico City 11200, Mexico.
  • Regalado-García AG; Laboratorio de Inmunología, Escuela Militar de Graduados de Sanidad, SEDENA, Mexico City 11200, Mexico.
  • Pineda-Gudiño RD; Hospital Central Militar, SEDENA, Mexico City 11200, Mexico.
  • García-Martínez A; Hospital Central Militar, SEDENA, Mexico City 11200, Mexico.
  • Juárez-Hernández F; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Farias-Contreras JP; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Fricke-Galindo I; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Pérez-Rubio G; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Falfán-Valencia R; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Buendia-Roldan I; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
  • Medina-Quero K; Laboratorio de Inmunología, Escuela Militar de Graduados de Sanidad, SEDENA, Mexico City 11200, Mexico.
  • Chavez-Galan L; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Int J Mol Sci ; 22(16)2021 Aug 05.
Article in English | MEDLINE | ID: covidwho-1341695
ABSTRACT
Overproduction of inflammatory cytokines is a keystone event in COVID-19 pathogenesis; TNF and its receptors (TNFR1 and TNFR2) are critical pro-inflammatory molecules. ADAM17 releases the soluble (sol) forms of TNF, TNFR1, and TNFR2. This study evaluated TNF, TNFRs, and ADAM17 at the protein, transcriptional, and gene levels in COVID-19 patients with different levels of disease severity. In total, 102 patients were divided into mild, moderate, and severe condition groups. A group of healthy donors (HD; n = 25) was included. Our data showed that solTNFR1 and solTNFR2 were elevated among the COVID-19 patients (p < 0.0001), without increasing the transcriptional level. Only solTNFR1 was higher in the severe group as compared to the mildly ill (p < 0.01), and the level was higher in COVID-19 patients who died than those that survived (p < 0.0001). The solTNFR1 level had a discrete negative correlation with C-reactive protein (p = 0.006, Rho = -0.33). The solADAM17 level was higher in severe as compared to mild disease conditions (p < 0.01), as well as in COVID-19 patients who died as compared to those that survived (p < 0.001). Additionally, a potential association between polymorphism TNFRSF1Ars767455 and a severe degree of disease was suggested. These data suggest that solTNFR1 and solADAM17 are increased in severe conditions. solTNFR1 should be considered a potential target in the development of new therapeutic options.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Receptors, Tumor Necrosis Factor, Type I / ADAM17 Protein / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22168423

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Receptors, Tumor Necrosis Factor, Type I / ADAM17 Protein / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22168423