Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection.
Life Sci Alliance
; 4(10)2021 10.
Article
in English
| MEDLINE | ID: covidwho-1342114
ABSTRACT
The duration of viral shedding is determined by a balance between de novo infection and removal of infected cells. That is, if infection is completely blocked with antiviral drugs (100% inhibition), the duration of viral shedding is minimal and is determined by the length of virus production. However, some mathematical models predict that if infected individuals are treated with antiviral drugs with efficacy below 100%, viral shedding may last longer than without treatment because further de novo infections are driven by entry of the virus into partially protected, uninfected cells at a slower rate. Using a simple mathematical model, we quantified SARS-CoV-2 infection dynamics in non-human primates and characterized the kinetics of viral shedding. We counterintuitively found that treatments initiated early, such as 0.5 d after virus inoculation, with intermediate to relatively high efficacy (30-70% inhibition of virus replication) yield a prolonged duration of viral shedding (by about 6.0 d) compared with no treatment.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Virus Shedding
/
COVID-19
/
COVID-19 Drug Treatment
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Lsa.202101049
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