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Functional, Clinical, and Sociodemographic Variables Associated with Risk of In-Hospital Mortality by COVID-19 in People over 80 Years Old.
Rodríguez-Sánchez, I; Redondo-Martín, M; Furones-Fernández, L; Méndez-Hinojosa, M; Chen-Chim, Á; Saavedra-Palacios, R; Gil-Gregorio, P.
  • Rodríguez-Sánchez I; Isabel Rodríguez-Sánchez. Geriatrics Department. Hospital Universitario Clínico San Carlos. Calle Profesor Martín Lagos s/n. 28040 Madrid. SPAIN. Phone number: (+34) 91 3303000. Email: isabelrs89@gmail.com.
J Nutr Health Aging ; 25(8): 964-970, 2021.
Article in English | MEDLINE | ID: covidwho-1343048
ABSTRACT

OBJECTIVES:

The objective is to assess the role of functional, clinical, and analytic parameters in predicting mortality in older patients hospitalized due to COVID-19.

DESIGN:

Cohort study with a mean follow-up of 12.8 days.

SETTING:

Public university hospital (Madrid, Spain).

PARTICIPANTS:

499 patients 80 and above consecutively admitted to a Spanish public university hospital between 4 March 2020 and 16 May 2020. MEASUREMENTS Mortality was the main outcome. Data of sociodemographic variables (age, sex, living), comorbidities, polypharmacy, functional status, date of hospital admission and length of stay was recorded. Clinical symptoms, laboratory and X-ray findings were collected at time of admission. For multivariant analysis, logistic regressions were performed to identify risk factors for death.

RESULTS:

Mean age was 86.7±4.4 with 37% of death. Mortality was associated with male gender [odds ratio (OR) 1.50; 95% confidence interval (CI) 1.01-2.24], with a 5-points increase on Barthel Index [OR 1.01 (95%CI 1.00-1.02)], higher Charlson Index score [OR 1.13 (95%CI 1.02-1.26)] and comorbidities [OR 1.28 (95%CI 1.06-1.53)], hyperpolipharmacy [OR 2.00 (95%CI 1.04-3.82)], unilateral pneumonia [OR 1.83 (95%CI 1.01-3.30)], higher levels of C-reactive protein [OR 1.09 (95%CI 1.06-1.12)] and creatine [OR 1.48 (95%CI 1.15-1.89)]. Higher oxygen levels were a protective factor [OR 0.92 (95%CI 0.89-0.95)].

CONCLUSIONS:

Functional status, being male, a higher burden of comorbidities, hyperpolipharmacy, unilateral pneumonia and some laboratory parameters predict in-hospital mortality in this older population. The knowledge of these mortality risk factors should be used to improve the survival of older hospitalized patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: J Nutr Health Aging Journal subject: Nutritional Sciences / Geriatrics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: J Nutr Health Aging Journal subject: Nutritional Sciences / Geriatrics Year: 2021 Document Type: Article