Structural features of an acidic polysaccharide with the potential of promoting osteoblast differentiation from Lycium ruthenicum Murr.
Nat Prod Res
; 34(16): 2249-2254, 2020 Aug.
Article
in English
| MEDLINE | ID: covidwho-1343564
ABSTRACT
The enhanced osteoblast differentiation is beneficial to the prevention of osteoporosis. In this study, a homogeneous polysaccharide (LRP-S2A) with the potential of promoting osteoblast differentiation was obtained from the fruits of Lycium ruthenicum, a traditional herb for treatment of postmenopausal metabolic disorders. Structural identification indicated that LRP-S2A, with a relative molecular weight of 2.65 × 106 Da and an uronic acid content of 41.8%, contained Rha, Ara, Gal, Glc and GlcA in a molar ratio of 1.00 2.07 0.57 2.59 4.33 and was composed of a backbone consisting of 6-O-Me-α-(1â4)-D-GlcpA, 2-O-acetyl-α-(1â4)-D-Glcp, α-(1â2,4)-L-Rhap, ß-(1â3)-D-Galp andα-(1â3,5)-L-Araf, and some branches consisting of 6-O-Me-α-(1â4)-D-GlcpA and terminal α-L-Araf. These results suggested that LRP-S2A with the potential of promoting osteoblast differentiation was a new acidic polysaccharide.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Osteoblasts
/
Polysaccharides
/
Cell Differentiation
/
Lycium
Topics:
Traditional medicine
Limits:
Animals
/
Humans
Language:
English
Journal:
Nat Prod Res
Year:
2020
Document Type:
Article
Affiliation country:
14786419.2018.1452014
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