Single breath counting is an effective screening tool for forced vital capacity in ALS.
Amyotroph Lateral Scler Frontotemporal Degener
; 22(sup1): 5-8, 2021.
Article
in English
| MEDLINE | ID: covidwho-1343595
ABSTRACT
Objective:
To measure the correlation between single breath counting (SBC) and forced vital capacity (liters, FVCL) in amyotrophic lateral sclerosis (ALS) patients and to define the utility of SBC for determining when patients meet the threshold for initiation of noninvasive positive pressure ventilation (FVC < 50% predicted [FVCpred]).Methods:
Both patient paced (SBCpp) or externally paced (SBCep) counting along with FVCL+pred and standard clinical data were collected. Linear regression was used to examine SBCpp and SBCep as a predictor of FVCL. Receiver operating characteristic curve analysis evaluated the sensitivity and specificity of SBC categorically predicting FVCpred of ≤50%.Results:
In 30 ALS patients, SBC explained a moderate proportion of the variance in FVCL (SBCpp R2= 0.431, p < 0.001; SBCep R2 = 0.511, p < 0.01); this proportion improved when including covariates (SBCpp R2= 0.635, p < 0.01; SBCep R2= 0.657, p < 0.01). Patients with minimal speech involvement performed similarly in unadjusted (SBCpp R2 = 0.511, p < 0.01; SBCep R2= 0.595, p < 0.01) and adjusted (SBCpp R2 = 0.634, p < 0.01; SBCep R2= 0.650, p < 0.01) models. SBCpp had 100% sensitivity and 60% specificity (area under curve (AUC) = 0.696) for predicting FVCpred <50%. SBCep had 100% sensitivity and 56% specificity (AUC = 0.696). With minimal speech involvement SBCpp and SBCep both had 100% sensitivity and 76.1% specificity (SPCpp AUC = 0.845; SBCep AUC = 0.857).Conclusions:
SBC explains a moderate proportion of variance in FVC and is an extremely sensitive marker of poor FVC. When FVC cannot be obtained, such as during the current COVID-19 pandemic, SBC is helpful in directing patient care.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Amyotrophic Lateral Sclerosis
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Amyotroph Lateral Scler Frontotemporal Degener
Year:
2021
Document Type:
Article
Affiliation country:
21678421.2021.1915337
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