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Is There a Rationale for Using Bacillus Calmette-Guerin Vaccine in Coronavirus Infection?
Maheshwari, Nidhi; Jain, Ayush.
  • Maheshwari N; Department of Pharmacology, Maulana Azad Medical College, New Delhi, India.
  • Jain A; Department of Pharmacology, Maulana Azad Medical College, New Delhi, India.
Viral Immunol ; 34(5): 300-306, 2021 06.
Article in English | MEDLINE | ID: covidwho-1343606
Semantic information from SemMedBD (by NLM)
1. BCG Vaccine ASSOCIATED_WITH Coronavirus Infections
Subject
BCG Vaccine
Predicate
ASSOCIATED_WITH
Object
Coronavirus Infections
2. BCG Vaccine PREVENTS Coronavirus Infections
Subject
BCG Vaccine
Predicate
PREVENTS
Object
Coronavirus Infections
3. BCG Vaccine TREATS Vulnerable Populations
Subject
BCG Vaccine
Predicate
TREATS
Object
Vulnerable Populations
4. BCG Vaccine ASSOCIATED_WITH Coronavirus Infections
Subject
BCG Vaccine
Predicate
ASSOCIATED_WITH
Object
Coronavirus Infections
5. BCG Vaccine PREVENTS Coronavirus Infections
Subject
BCG Vaccine
Predicate
PREVENTS
Object
Coronavirus Infections
6. BCG Vaccine TREATS Vulnerable Populations
Subject
BCG Vaccine
Predicate
TREATS
Object
Vulnerable Populations
ABSTRACT
Coronavirus disease 2019 (COVID-19) has become a global pandemic in 2020. The pathogen responsible for the COVID-19 has been found to be coronavirus (2019-nCoV) with human transmission through droplets, airway secretions, and even direct contact with host. Currently multiple drugs and their combinations are being tried for the treatment of the COVID-19 disease, but none approved. In absence of definitive and approved treatment, it is imperative that prevention of COVID-19 infection is of utmost importance. For the same, face masks, hand hygiene, isolation, and quarantine are being practiced all over the world. However much successful these methods be, they cannot be used for a very long time. Thus, it becomes necessary that a vaccine be developed for the disease so that the further spread could be halted. Some reports suggest the use of Bacillus Calmette-Guerin (BCG) vaccine as the prophylaxis for coronavirus. BCG vaccine is a live attenuated vaccine, used for prophylaxis of Mycobacterium tuberculosis and is present in the essential list of the World Health Organization as well as immunization programs of many countries. Immunostimulatory antiviral effects of BCG vaccine are well known. At present, there are no published evidence available to support the use of BCG vaccine for the prevention of coronavirus infection. However, there have been speculations on enhanced immunity with BCG vaccine, which might be useful in prevention of coronavirus infection. Results from the clinical studies of BCG vaccine in vulnerable population are required to confirm this hypothesis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2021 Document Type: Article Affiliation country: Vim.2020.0079

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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2021 Document Type: Article Affiliation country: Vim.2020.0079