Antiviral Activity of Ribosome-Inactivating Proteins.
Toxins (Basel)
; 13(2)2021 01 22.
Article
in English
| MEDLINE | ID: covidwho-1344393
ABSTRACT
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the difficulty in treating viral infections. On the other hand, there is a growing need to control crop diseases without resorting to the use of phytosanitary products which are very harmful to the environment and in this respect, RIPs have been shown as a promising tool that can be used to obtain transgenic plants resistant to viruses. The way in which RIPs exert their antiviral effect continues to be the subject of intense research and several mechanisms of action have been proposed. The purpose of this review is to examine the research studies that deal with this matter, placing special emphasis on the most recent findings.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Plant Diseases
/
Toxins, Biological
/
Viruses
/
Virus Diseases
/
Protein Synthesis Inhibitors
/
Pest Control, Biological
/
Plants, Genetically Modified
/
Ribosome Inactivating Proteins
Limits:
Animals
/
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Toxins13020080
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