Your browser doesn't support javascript.
Glucocorticoid-Dependent Mechanisms of Brain Tolerance to Hypoxia.
Rybnikova, Elena; Nalivaeva, Natalia.
  • Rybnikova E; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
  • Nalivaeva N; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia.
Int J Mol Sci ; 22(15)2021 Jul 26.
Article in English | MEDLINE | ID: covidwho-1344938
ABSTRACT
Adaptation of organisms to stressors is coordinated by the hypothalamic-pituitary-adrenal axis (HPA), which involves glucocorticoids (GCs) and glucocorticoid receptors (GRs). Although the effects of GCs are well characterized, their impact on brain adaptation to hypoxia/ischemia is still understudied. The brain is not only the most susceptible to hypoxic injury, but also vulnerable to GC-induced damage, which makes studying the mechanisms of brain hypoxic tolerance and resistance to stress-related elevation of GCs of great importance. Cross-talk between the molecular mechanisms activated in neuronal cells by hypoxia and GCs provides a platform for developing the most effective and safe means for prevention and treatment of hypoxia-induced brain damage, including hypoxic pre- and post-conditioning. Taking into account that hypoxia- and GC-induced reprogramming significantly affects the development of organisms during embryogenesis, studies of the effects of prenatal and neonatal hypoxia on health in later life are of particular interest. This mini review discusses the accumulated data on the dynamics of the HPA activation in injurious and non-injurious hypoxia, the role of the brain GRs in these processes, interaction of GCs and hypoxia-inducible factor HIF-1, as well as cross-talk between GC and hypoxic signaling. It also identifies underdeveloped areas and suggests directions for further prospective studies.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pituitary-Adrenal System / Signal Transduction / Hypoxia, Brain / Ischemic Preconditioning / Disease Resistance / Glucocorticoids / Hypothalamo-Hypophyseal System Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22157982

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pituitary-Adrenal System / Signal Transduction / Hypoxia, Brain / Ischemic Preconditioning / Disease Resistance / Glucocorticoids / Hypothalamo-Hypophyseal System Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms22157982