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Maternal SARS-CoV-2 infection during pregnancy: possible impact on the infant.
Morhart, Patrick; Mardin, Christian; Rauh, Manfred; Jüngert, Jörg; Hammersen, Johanna; Kehl, Sven; Schuh, Wolfgang; Maier-Wohlfart, Sigrun; Hermes, Katharina; Neubert, Antje; Schneider, Michael; Hein, Alexander; Woelfle, Joachim; Schneider, Holm.
  • Morhart P; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
  • Mardin C; Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany.
  • Rauh M; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
  • Jüngert J; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
  • Hammersen J; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
  • Kehl S; Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, Erlangen, Germany.
  • Schuh W; Division of Molecular Immunology, University of Erlangen-Nürnberg, Erlangen, Germany.
  • Maier-Wohlfart S; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
  • Hermes K; Hauner'sches Kinderspital, University of Munich, Munich, Germany.
  • Neubert A; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
  • Schneider M; Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, Erlangen, Germany.
  • Hein A; Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, Erlangen, Germany.
  • Woelfle J; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany.
  • Schneider H; Department of Pediatrics, University of Erlangen-Nürnberg, Loschgestr. 15, 91054, Erlangen, Germany. holm.schneider@uk-erlangen.de.
Eur J Pediatr ; 181(1): 413-418, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1345122
ABSTRACT
The risk and potential consequences of mother-to-child transmission of severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) during pregnancy are still a matter of debate. We studied the impact of SARS-CoV-2 infection on 56 complete households, including 27 newborns whose mothers were pregnant when exposed to the virus. Two PCR-confirmed perinatal SARS-CoV-2 transmissions with mild symptoms in affected neonates were recorded. In addition, we observed a severe eye malformation (unilateral microphthalmia, optic nerve hypoplasia, and congenital retinopathy) associated with maternal SARS-CoV-2 infection in weeks 5 and 6 of embryonic development. This embryopathy could not be explained by other infectious agents, genetic factors, drug use, or maternal disease during pregnancy. Eight other women with a history of SARS-CoV-2 infection prior to gestational week 12, however, delivered healthy infants.

Conclusion:

The repeated occurrence of mother-to-child transmission in our cohort with risks that remain incompletely understood, such as long-term effects and the possibility of an embryopathy, should sensitize researchers and stimulate further studies as well as support COVID-19 vaccination recommendations for pregnant women. Trial registration number NCT04741412. Date of registration November 18, 2020 What is Known •Materno-fetal transmission of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) during pregnancy has rarely been reported so far, but was demonstrated in isolated cases. What is New •In a study of complete households with documented SARS-CoV-2 infection, including a cohort of pregnant women, we observed perinatal coronavirus transmission at a higher frequency than expected. •We also describe a newborn boy with an eye malformation reminiscent of rubella embryopathy but associated with early gestation SARS-CoV-2 infection of his mother. •A coronavirus-related embryopathy, reported here for the first time, is a finding that requires further investigation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Randomized controlled trials Topics: Long Covid / Vaccines Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Language: English Journal: Eur J Pediatr Year: 2022 Document Type: Article Affiliation country: S00431-021-04221-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Randomized controlled trials Topics: Long Covid / Vaccines Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Language: English Journal: Eur J Pediatr Year: 2022 Document Type: Article Affiliation country: S00431-021-04221-w