Your browser doesn't support javascript.
Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation.
Pretzel, Shannon; Kuhn, Katherine; Pal, Lubna; Polotsky, Alex; Taylor, Hugh S; Zhang, Heping; Robins, Jared; Young, Steven L; Santoro, Nanette.
  • Pretzel S; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Kuhn K; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Pal L; Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA.
  • Polotsky A; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.
  • Taylor HS; Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA.
  • Zhang H; Collaborative Center for Statistics in Science, Yale School of Public Health, New Haven, CT, USA.
  • Robins J; Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, USA.
  • Young SL; Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Santoro N; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA. Nanette.Santoro@cuanschutz.edu.
Reprod Sci ; 29(2): 620-626, 2022 02.
Article in English | MEDLINE | ID: covidwho-1345228
ABSTRACT
The Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis (PREGnant) Trial (clinicaltrials.gov no. NCT04173169) was designed to test the hypothesis that 60-day pre-treatment with an oral GnRH antagonist in women with documented endometriosis and planning an IVF cycle will result in a superior live birth rate to placebo. Eight hundred fourteen women are required from 4 national sites. To determine the feasibility of using an electronic medical record (EMR)-based strategy to recruit 204 participants at the Colorado site, we conducted a survey of women within the UCHealth system. Eligible women, identified using relevant ICD-10 codes, were invited to complete a 6-question survey to assess planned utilization of IVF, potential interest in participation, and whether delays in treatment due to COVID-19 would influence their decision to participate. Of 6354 age-eligible women with an endometriosis diagnosis, 421 had a concurrent infertility diagnosis. After eliminating duplicates, 212 were emailed a survey; 76 (36%) responded, 6 of whom reported no endometriosis diagnosis. Of the remaining 70, 29 (41%) were planning fertility treatment; only 19 planned IVF. All 19 expressed interest in participation. COVID-19 delays in treatment were not considered as a factor affecting participation by 8/19; the remaining 11 felt that it would "somewhat" affect their decision. None reported that they would not consider participation because of COVID-19. EMR-based recruitment for an endometriosis clinical trial is feasible although the overall yield of participants is low. Delays in treatment due to COVID-19 did not appear to overly influence potential recruitment.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Fertilization in Vitro / Health Knowledge, Attitudes, Practice / Patient Selection / Research Subjects / Endometriosis / Fertility Agents, Female / COVID-19 / Hormone Antagonists / Infertility, Female Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Pregnancy / Young adult Country/Region as subject: North America Language: English Journal: Reprod Sci Journal subject: Reproductive Medicine Year: 2022 Document Type: Article Affiliation country: S43032-021-00705-0

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Fertilization in Vitro / Health Knowledge, Attitudes, Practice / Patient Selection / Research Subjects / Endometriosis / Fertility Agents, Female / COVID-19 / Hormone Antagonists / Infertility, Female Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Pregnancy / Young adult Country/Region as subject: North America Language: English Journal: Reprod Sci Journal subject: Reproductive Medicine Year: 2022 Document Type: Article Affiliation country: S43032-021-00705-0