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Challenges in interpreting cytokine data in COVID-19 affect patient care and management.
Wang, Stephen Y; Takahashi, Takehiro; Pine, Alexander B; Damsky, William E; Simonov, Michael; Zhang, Yanhua; Kieras, Elizabeth; Price, Christina C; King, Brett A; Siegel, Mark D; Desir, Gary V; Lee, Alfred I; Iwasaki, Akiko; Chun, Hyung J.
  • Wang SY; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Takahashi T; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Pine AB; Section of Hematology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Damsky WE; VA Connecticut Healthcare System, West Haven, Connecticut, United States of America.
  • Simonov M; Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Zhang Y; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Kieras E; Pfizer, Inc., New York, New York, United States of America.
  • Price CC; Pfizer, Inc., New York, New York, United States of America.
  • King BA; Section of Allergy and Clinical Immunology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Siegel MD; Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Desir GV; Section of Pulmonology and Critical Care Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Lee AI; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Iwasaki A; Section of Hematology, Yale School of Medicine, New Haven, Connecticut, United States of America.
  • Chun HJ; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America.
PLoS Biol ; 19(8): e3001373, 2021 08.
Article in English | MEDLINE | ID: covidwho-1346324
ABSTRACT
Challenges in using cytokine data are limiting Coronavirus Disease 2019 (COVID-19) patient management and comparison among different disease contexts. We suggest mitigation strategies to improve the accuracy of cytokine data, as we learn from experience gained during the COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study Limits: Humans Language: English Journal: PLoS Biol Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Journal.pbio.3001373

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study Limits: Humans Language: English Journal: PLoS Biol Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Journal.pbio.3001373