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Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf.
Orlando, Giustino; Chiavaroli, Annalisa; Adorisio, Sabrina; Delfino, Domenico V; Brunetti, Luigi; Recinella, Lucia; Leone, Sheila; Zengin, Gokhan; Acquaviva, Alessandra; Angelini, Paola; Flores, Giancarlo Angeles; Venanzoni, Roberto; Di Simone, Simonetta Cristina; Di Corpo, Francesca; Mocan, Andrei; Menghini, Luigi; Ferrante, Claudio.
  • Orlando G; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Chiavaroli A; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Adorisio S; Section of Pharmacology, Department of Medicine and Surgery, Foligno Nursing School, University of Perugia, 06100 Perugia, Italy.
  • Delfino DV; Section of Pharmacology, Department of Medicine and Surgery, Foligno Nursing School, University of Perugia, 06100 Perugia, Italy.
  • Brunetti L; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Recinella L; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Leone S; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Zengin G; Department of Biology, Science Faculty, Selcuk University, Campus, Konya 42130, Turkey.
  • Acquaviva A; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Angelini P; Veridia Italia Srl, Via Raiale 285, 65100 Pescara, Italy.
  • Flores GA; Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
  • Venanzoni R; Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
  • Di Simone SC; Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
  • Di Corpo F; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Mocan A; Department of Pharmacy, Botanic Garden "Giardino dei Semplici", Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.
  • Menghini L; Faculty of Pharmacy, "Iuliu HaTieganu" University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
  • Ferrante C; Laboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Molecules ; 26(15)2021 Jul 22.
Article in English | MEDLINE | ID: covidwho-1346513
ABSTRACT
Prunus mahaleb L. fruit has long been used in the production of traditional liqueurs. The fruit also displayed scavenging and reducing activity, in vitro. The present study focused on unravelling peripheral and central protective effects, antimicrobial but also anti-COVID-19 properties exerted by the water extract of P. mahaleb. Anti-inflammatory effects were studied in isolated mouse colons exposed to lipopolysaccharide. Neuroprotection, measured as a blunting effect on hydrogen-peroxide-induced dopamine turnover, was investigated in hypothalamic HypoE22 cells. Antimicrobial effects were tested against different Gram+ and Gram- bacterial strains. Whereas anti-COVID-19 activity was studied in lung adenocarcinoma H1299 cells, where the gene expression of ACE2 and TMPRSS2 was measured after extract treatment. The bacteriostatic effects induced on Gram+ and Gram- strains, together with the inhibition of COX-2, TNFα, HIF1α, and VEGFA in the colon, suggest the potential of P. mahaleb water extract in contrasting the clinical symptoms related to ulcerative colitis. The inhibition of the hydrogen peroxide-induced DOPAC/DA ratio indicates promising neuroprotective effects. Finally, the downregulation of the gene expression of ACE2 and TMPRSS2 in H1299 cells, suggests the potential to inhibit SARS-CoV-2 virus entry in the human host. Overall, the results support the valorization of the local cultivation of P. mahaleb.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacteria / Plant Extracts / Colon / Neuroprotection / SARS-CoV-2 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans / Male Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26154422

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacteria / Plant Extracts / Colon / Neuroprotection / SARS-CoV-2 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans / Male Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26154422