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EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus.
Tsvetkov, Vladimir; Varizhuk, Anna; Kozlovskaya, Liubov; Shtro, Anna; Lebedeva, Olga; Komissarov, Andrey; Vedekhina, Tatjana; Manuvera, Valentin; Zubkova, Olga; Eremeev, Artem; Shustova, Elena; Pozmogova, Galina; Lioznov, Dmitry; Ishmukhametov, Aydar; Lazarev, Vassili; Lagarkova, Maria.
  • Tsvetkov V; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia; World-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Trubetskaya
  • Varizhuk A; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medici
  • Kozlovskaya L; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Poselok Instituta Poliomiyelita 8, 108819, Moscow, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Nakhimovsky av
  • Shtro A; Smorodintsev Research Institute of Influenza, Professora Popova str., 15/17, 197376, Sankt-Peterburg, Russia.
  • Lebedeva O; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medici
  • Komissarov A; Smorodintsev Research Institute of Influenza, Professora Popova str., 15/17, 197376, Sankt-Peterburg, Russia.
  • Vedekhina T; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia.
  • Manuvera V; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medici
  • Zubkova O; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia.
  • Eremeev A; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medici
  • Shustova E; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Poselok Instituta Poliomiyelita 8, 108819, Moscow, Russia.
  • Pozmogova G; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia.
  • Lioznov D; Smorodintsev Research Institute of Influenza, Professora Popova str., 15/17, 197376, Sankt-Peterburg, Russia.
  • Ishmukhametov A; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Poselok Instituta Poliomiyelita 8, 108819, Moscow, Russia; Institute of Translational Medicine and Biotechnology, Sechenov Moscow State Medical University, Nakhimovsky av
  • Lazarev V; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medici
  • Lagarkova M; Federal Research and Clinical Center of Physical Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya str. 1a, 119435, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medici
Biochimie ; 191: 27-32, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1347500
ABSTRACT
In the search for anti-SARS-CoV-2 drugs, much attention is given to safe and widely available native compounds. The green tea component epigallocatechin 3 gallate (EGCG) is particularly promising because it reportedly inhibits viral replication and viral entry in vitro. However, conclusive evidence for its predominant activity is needed. We tested EGCG effects on the native virus isolated from COVID-19 patients in two independent series of experiments using VERO cells and two different treatment schemes in each series. The results confirmed modest cytotoxicity of EGCG and its substantial antiviral activity. The preincubation scheme aimed at infection prevention has proven particularly beneficial. We complemented that finding with a detailed investigation of EGCG interactions with viral S-protein subunits, including S2, RBD, and the RBD mutant harboring the N501Y mutation. Molecular modeling experiments revealed N501Y-specific stacking interactions in the RBD-ACE2 complex and provided insight into EGCG interference with the complex formation. Together, these findings provide a molecular basis for the observed EGCG effects and reinforce its prospects in COVID-19 prevention therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Catechin / SARS-CoV-2 / COVID-19 Drug Treatment / Mutation Limits: Animals Language: English Journal: Biochimie Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Catechin / SARS-CoV-2 / COVID-19 Drug Treatment / Mutation Limits: Animals Language: English Journal: Biochimie Year: 2021 Document Type: Article