Hypertriglyceridemia during hospitalization independently associates with mortality in patients with COVID-19.
J Clin Lipidol
; 15(5): 724-731, 2021.
Article
in English
| MEDLINE | ID: covidwho-1347674
ABSTRACT
BACKGROUND:
Alteration in blood triglyceride levels have been found in patients with coronavirus disease 2019 (COVID-19). However, the association between hypertriglyceridemia and mortality in COVID-19 patients is unknown.OBJECTIVE:
To investigate the association between alteration in triglyceride level and mortality in hospitalized COVID-19 patients.METHODS:
We conducted a retrospective study of 600 hospitalized patients with COVID-19 diagnosis (ICD10CMU07.1) and/or SARS-CoV-2 positive testing results between March 1, 2020 and December 21, 2020 at a tertiary academic medical center in Milwaukee, Wisconsin. De-identified data, including demographics, medical history, and blood triglyceride levels were collected and analyzed. Of the 600 patients, 109 patients died. The triglyceride value on admission was considered the baseline and the peak was defined as the highest level reported during the entire period of hospitalization. Hypertriglyceridemia was defined as greater than 150 mg/dl. Logistic regression analyses were performed to evaluate the association between hypertriglyceridemia and mortality.RESULTS:
There was no significant difference in baseline triglyceride levels between non-survivors (n = 109) and survivors (n = 491) [Median 127 vs. 113 mg/dl, p = 0.213]. However, the non-survivors had significantly higher peak triglyceride levels during hospitalization [Median 179 vs. 134 mg/dl, p < 0.001]. Importantly, hypertriglyceridemia independently associated with mortality [odds ratio=2.3 (95% CI 1.4-3.7, p = 0.001)], after adjusting for age, gender, obesity, history of hypertension and diabetes, high CRP, high leukocyte count and glucocorticoid treatment in a multivariable logistic regression model.CONCLUSIONS:
Hypertriglyceridemia during hospitalization is independently associated with 2.3 times higher mortality in COVID-19 patients. Prospective studies are needed to independently validate this retrospective analysis.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hypertriglyceridemia
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Clin Lipidol
Journal subject:
Biochemistry
/
Metabolism
Year:
2021
Document Type:
Article
Affiliation country:
J.jacl.2021.08.002
Similar
MEDLINE
...
LILACS
LIS