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Asthma Disease Status, COPD, and COVID-19 Severity in a Large Multiethnic Population.
Huang, Brian Z; Chen, Zhanghua; Sidell, Margo A; Eckel, Sandrah P; Martinez, Mayra P; Lurmann, Fred; Thomas, Duncan C; Gilliland, Frank D; Xiang, Anny H.
  • Huang BZ; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, Calif.
  • Chen Z; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, Calif.
  • Sidell MA; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif.
  • Eckel SP; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, Calif.
  • Martinez MP; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif.
  • Lurmann F; Sonoma Technology, Petaluma, Calif.
  • Thomas DC; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, Calif.
  • Gilliland FD; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, Calif.
  • Xiang AH; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, Calif. Electronic address: anny.h.xiang@kp.org.
J Allergy Clin Immunol Pract ; 9(10): 3621-3628.e2, 2021 10.
Article in English | MEDLINE | ID: covidwho-1347677
ABSTRACT

BACKGROUND:

Current studies of asthma history on coronavirus disease 2019 (COVID-19) outcomes are limited and lack consideration of disease status.

OBJECTIVE:

To conduct a population-based study to assess asthma disease status and chronic obstructive pulmonary disease (COPD) in relation to COVID-19 severity.

METHODS:

Patients diagnosed with COVID-19 (n = 61,338) in a large, diverse integrated health care system were identified. Asthma/COPD history, medication use, and covariates were extracted from electronic medical records. Asthma patients were categorized into those with and without clinical visits for asthma 12 or fewer months prior to COVID-19 diagnosis and labeled as active and inactive asthma, respectively. Primary outcomes included COVID-19-related hospitalizations, intensive respiratory support (IRS), and intensive care unit admissions within 30 days, and mortality within 60 days after COVID-19 diagnosis. Logistic and Cox regression were used to relate COVID-19 outcomes to asthma/COPD history.

RESULTS:

The cohort was 53.9% female and 66% Hispanic and had a mean age of 43.9 years. Patients with active asthma had increased odds of hospitalization, IRS, and intensive care unit admission (odds ratio 1.47-1.66; P < .05) compared with patients without asthma or COPD. No increased risks were observed for patients with inactive asthma. Chronic obstructive pulmonary disease was associated with increased risks of hospitalization, IRS, and mortality (odds ratio and hazard ratio 1.27-1.67; P < .05). Among active asthma patients, those using asthma medications had greater than 25% lower odds for COVID-19 outcomes than those without medication.

CONCLUSIONS:

Patients with asthma who required clinical care 12 or fewer months prior to COVID-19 or individuals with COPD history are at increased risk for severe COVID-19 outcomes. Proper medication treatment for asthma may lower this risk.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: J Allergy Clin Immunol Pract Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: J Allergy Clin Immunol Pract Year: 2021 Document Type: Article