Lack of neutralizing activity in nonconvalescent sera, regardless of ABO blood group and anti-A isoagglutinin titer.
J Clin Virol Plus
; 1(3): 100035, 2021 Sep.
Article
in English
| MEDLINE | ID: covidwho-1347690
ABSTRACT
Background:
Several ABO blood groups have been associated with the likelihood of infection, severity, and/or outcome of COVID-19 in hospitalized cohorts, raising the hypothesis that anti-A isoagglutinins in non-A-group recipients could act as neutralizing antibodies against SARS-CoV-2. Materials andmethods:
We run live virus neutralization tests using sera from 58 SARS-CoV-2 seronegative blood donors (27 O-group and 31 A-group) negatives for SARS-CoV-2 IgG to investigate what degree of neutralizing activity could be detected in their sera and eventual correlation with anti-A isoagglutinin titers.Results:
We could not find clinically relevant neutralizing activity in any blood group, regardless of anti-isoagglutinin titer.Discussion:
Our findings suggest that mechanisms other than neutralization explain the differences in outcomes from COVID19 seen in different ABO blood groups.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
J Clin Virol Plus
Year:
2021
Document Type:
Article
Affiliation country:
J.jcvp.2021.100035
Similar
MEDLINE
...
LILACS
LIS